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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsies SRC President cycles to raise money for registration

2017-11-27

Asive Dlanjwa, Bloemfontein SRC President, will cycle to Cape Town to
raise money for the 2018 registrations.
Photo: Moeketsi Mogotsi

“When I came to the University of the Free State (UFS), all I had was a R50 note and I did not know how I was going to register.” This is what Bloemfontein Campus SRC President, Asive Dlanjwa, encountered when he arrived at the UFS. He says the biggest struggle for students is not having finances for registration at the beginning of the year.

R2 million to be raised for 2018 registration
It is for this reason that Dlanjwa will be partaking in the Right to Learn Cycle tour challenge from 27 November to 4 December 2017. The Student Representative Council (SRC), in partnership with Institutional Advancement, came up with this initiative to cycle from Bloemfontein to Cape Town in eight days in an effort to raise R2 million for 2018 registration.

Bringing hope to prospective students and their families
Dlanjwa says, “We want to give access to as many students as possible. This initiative is not only about the students, it’s about giving hope to their families and taking them out of poverty.” He recalls an incident where a student went to the SRC offices to seek help at the beginning of the year, with nothing but an identity document and the clothes he had on. The student had been sleeping at the Bloemfontein Tourism Centre because he had no money for accommodation and registration. “These are the types of cases that we have to deal with at the start of each year,” says Dlanjwa.

He urges the community to partner with them in ensuring that many students get access to higher education by donating money through the Give-n-gain page. Dlanjwa, joined by a few more guest cyclists, left Bloemfontein on Monday 27 November 2017 and are expected to arrive in Cape Town on Monday 4 December 2017.

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