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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

CHE lifts notice of withdrawal of UFS LLB degree’s accreditation status

2017-11-16

The Council on Higher Education (CHE) has lifted the notice of withdrawal of the accreditation status of the University of the Free State’s (UFS) LLB degree. The degree is conditionally accredited with a progress report required in October 2018.

The Faculty of Law received this response to its Improvement Plan for the LLB degree from the CHE on 14 November 2017.

During 2016, a national review was conducted on all LLB programmes in order to strengthen the quality of legal education provision at all South African universities. On 30 March 2017, the Higher Education Quality Committee (HEQC) approved the findings of the National Reviews Committee (NRC) with regard to the LLB programme at the UFS, and placed the qualification on a notice of withdrawal of accreditation.

The decision of the CHE this week comes after the faculty submitted the Improvement Plan during early October 2017. This plan sets out for the CHE the changes that will be effected in the LLB programme for 2018 and 2019 and provides an outline of the new LLB curriculum it intends to introduce in 2020.

“The university’s executive management is extremely pleased about the outcome and welcomes the lifting of the notice of withdrawal of accreditation status, as it comes during a critical time of the year when the new cohort of Law students is completing their Grade 12 exams. Prof Caroline Nicholson, Dean of the Faculty of Law, and her team are commended for the considerable effort put into the submission and the extensive attention that was specifically given to concerns raised by the CHE in terms of the number of credits in the degree,” says Prof Francis Petersen, Rector and Vice-Chancellor of the UFS.

“There is hard work to be done going forward in ensuring that the UFS LLB degree is the very best on offer in South Africa, but with the continued support and commitment of the staff and students in the Faculty of Law, this vision is achievable,” says Prof Nicholson.

Released by:
Lacea Loader (Director: Communication and Brand Management)
Telephone: +27 51 401 2584 | +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

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