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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Physics Research Chair receives more funding

2017-11-20

Prof Hendrik Swart, Senior Researcher Professor in the
Department of Physics at UFS.
Photo: Charl Devenish

A research project into low-energy lighting using phosphor materials for light emitting diodes (LEDs) at the Department of Physics at the University of the Free State (UFS) has received further recognition.

The South African Research Chairs Initiative (SARChi) has awarded further funding for the Research Chair in Solid State Luminescent and Advanced Materials situated in the department. Prof Hendrik Swart, a Senior Research Professor in the Department of Physics, says this means that the Chair will carry on receiving funds from SARChi for another five years. The Initiative also awarded Prof Swart in 2012 for the research, which resulted in funding for equipment and among others, bursaries.

Better light emission in LED’s
The research focuses on better light emission of phosphor powers in LEDs. It is also looking into improving LED displays in flat screens. The research into solar cells has shown that phosphors can also increase their efficiency by increasing the range of light frequencies, which convert into electricity. It also entails that glow-in-the-dark coatings absorb light during the day and emit it at night.

Prof Swart says over the next five years the research will focus on developing and producing devices that emit better light using the substances already developed. “We need to make small devices to see if they are better than those we already have.” In practical terms, it means they want a farmer’s water pump that works with solar energy to work better with less energy input.”

Device that simulates sunlight
Prof Swart says the renewal of the Chair’s funding means the department can now get equipment to enhance its research such as a solar simulator. The solar simulator uses white LEDs whose intensity output and wavelengths can be tuned. The output is measured in number of suns. It enables researchers to work in a laboratory with a device that simulates sunlight.

According to Prof Swart the long-term benefit of the research will result in more environmentally friendly devices which use less energy, are brighter and give a wider viewing field.

About 10 postdoctoral researchers are working on the studies done by the Chair in collaboration with the Council for Scientific and Industrial Research.

The Research Chair Initiative aims to improve the research capacity at public universities to produce high-quality postgraduate students, research and innovative outputs. The criterion for evaluating the department’s Chair includes aspects such as how much development has occurred over the past five years. The assessors look at features such as the number of students the research entity has trained and how many publications the research team has produced.

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