Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof Loyiso Jita appointed as UFS Dean of Education
2017-11-22

 Description: Prof Melanie Walker, Research chair into Higher Education gets boost for five more years Tags: Prof Melanie Walker, Research chair into Higher Education gets boost for five more years

Prof Loyiso Jita, UFS Dean of Education
Photo: Johan Roux

The Council of the University of the Free State (UFS) has approved the appointment of Prof Loyiso Jita as Dean of Education during its quarterly meeting held on the Bloemfontein Campus on 17 November 2017.

“Prof Jita has a strong academic background and a good understanding of the higher-education sector. I look forward to working with him and to realise the vision of the university as a research-led, student-centred and regionally engaged university that contributes to development and social justice through the production of globally competitive graduates and knowledge,” says Prof Francis Petersen, UFS Rector and Vice-Chancellor.

“It is indeed a privilege for me to lead a team of committed teachers and researchers in the faculty, providing excellent service to our undergraduate and postgraduate students. I thank the Council and executive management for their trust in me,” says Prof Jita.

In January 2017, Prof Jita was appointed as the Acting Dean of the Faculty of Education at the UFS. He will assume the position of Dean of the Faculty of Education on 1 December 2017.

Prof Jita began his career as a Science and Mathematics teacher, after graduating from Wits University in 1988. He later took up a lectureship position at the University of Zululand, where he was awarded a Fulbright scholarship to read for a PhD at Michigan State University in the USA. In the mid-1990s, he worked as a policy researcher at the University of KwaZulu-Natal where he, among others, helped to compile the submission on the Violation of Educational Rights of South Africans during apartheid, to the Truth and Reconciliation Commission (TRC).

He joined the University of Pretoria (UP) in 2001, after returning from a post-doctoral fellowship at the Northwestern University in Chicago, and was later appointed Director of the Joint Centre for Science, Mathematics and Technology Education (JCSMTE). He left the UP in 2008 for an appointment as an associate professor at the University of South Africa (Unisa), where he later became the inaugural Director of the School of Education. In 2011, he became a full professor and was appointed as the acting Deputy Executive Dean in the College of Human Sciences at Unisa.

In 2012, he joined the UFS as Research Professor in the School of Mathematics, Natural Sciences, and Technology Education. In November 2014, he was appointed as the SANRAL Chair for Science and Mathematics Education. Professor Jita has published many articles on instructional leadership, teacher development and change, Science and Mathematics education, and has presented over 50 papers at local and international conferences. He has also supervised to completion more than 37 master’s and PhD graduates, and is currently the editor-in-chief for the accredited journal, Perspectives in Education (PIE).

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept