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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Two honorary doctorates part of highlights at UFS graduations
2017-11-30


  Description: Dec gradspeakers Tags: Graduation Ceremonies, Prof Paul Holloway, Marius Botha, Joyene Isaacs, Likeleli Monyamane, Leah Molatseli, Dr Imtiaz Sooliman

  Leah Molatseli (left), Dr Imtiaz Sooliman, and Likeleli Monyamane will be
  the guest speakers during the End-of-year Graduation Ceremonies
  at the University of the Free State.
  Photos: Supplied, www.mudboots.co.za

Roads and entrance closed due to roadworks on the Bloemfontein Campus

Graduation Livestream

Two honorary doctorates and a Chancellor’s medal will be some of the highlights during the End-of-year Graduation Ceremonies at the University of the Free State (UFS).

The Callie Human Centre on the Bloemfontein Campus will once again welcome graduates, their parents, friends, and relatives for the celebrations on 6 and 7 December 2017. A total number of 1226 qualifications, including diplomas, certificates, and degrees, will be conferred during the two days.

Altogether 40 doctorates and 109 master’s degrees will be awarded. Most doctorates (19) will be awarded in the Faculty of Natural and Agricultural Sciences, while most of the master’s degrees (27) are in the same faculty.

Prof Holloway, Botha, and Isaacs honoured
Prof Paul Holloway (Natural and Agricultural Sciences) and Marius Botha (Law) will receive honorary doctorates during the afternoon ceremony on 7 December 2017, while Joyene Isaacs (Natural and Agricultural Sciences) will be honoured with a Chancellor’s Medal.

Prof Holloway is an internationally acclaimed expert in the science and technology of surfaces, thin films, and nanoparticles, and Botha has played a significant role in financial planning in South Africa. Isaacs is the Head of Department of the Western Cape Department of Agriculture, and her department has been nominated by the South African Institute of Government Auditors as the best government department. 

Young leader, young alumnus, and humanitarian

Likeleli Monyamane, Leah Molatseli, and Dr Imtiaz Sooliman will be the guest speakers at the ceremonies.

Monyamane, a UFS Council member, will address graduates on 6 December 2017 during the morning ceremony. She is one of 15 young leaders selected to represent Lesotho as participants in the Mandela Washington Fellowship in the United States. In 2016, Molatseli, the speaker during the afternoon session on 6 December 2017, launched South Africa’s first legal ecommerce website, Lenoma Legal, and is the university’s most recent Young Alumnus of the Year.

Dr Sooliman, the speaker at both ceremonies on 7 December 2017, is the founder and Director of the Gift of the Givers Foundation. He has received more than 100 national and international awards, citations, commendations, and special recognition for his humanitarian work.

Date: 6 December 2017
Time: 09:00: All qualifications up to Honours degrees in the Faculty of Economic and Management Sciences (including the Business School) and the Faculty of Natural and Agricultural Sciences
14:30: All qualifications up to Honours degrees in the Faculties of Education, Law, the Humanities, and Theology

Date: 7 December 2017

Time: 09:00: All qualifications up to Honours degrees in the Faculty of Health Sciences and Educational qualifications in Open Distance Learning – South Campus
14:30: Master’s and Doctoral degrees in all faculties

For information about the ceremonies, click here to visit the graduation home page.

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