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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

SmartDrive devices give UFS wheelchair users more independence

2017-12-01

From the left, are: David Mashape; Martie Miranda, Head of the
Center for Universal Access and Disability Support at the UFS;
and Lawrence Qamba, celebrating the recent acquisition
of two SmartDrive Power Assist devices.
Photo: Johan Roux

Students who make use of wheelchairs at the University of the Free State (UFS) will now be able to move around campus more independently than before. This is thanks to two SmartDrive Power Assist devices acquired by the university.

Accessibility is very important to the institution and with these devices clipping onto a manual wheelchair to make it motorised, students will not have to ask for help that often. It will assist them in overcoming obstacles they face every day.

Different surfaces pose different challenges
According to Martie Miranda, Head of the Center for Universal Access and Disability Support (CUADS), one of the most important advantages of the SmartDrive machines is that it enhances the independence of students. The devices were bought with funds received from the Department of Higher Education and Training specifically allocated for accessibility and infrastructure.

“While the UFS is addressing inaccessibility on its campuses, which will take time, this will help to motorise wheelchairs for wheelchair users to move around more easily. Students can now move around independently without necessarily asking for help, for example, to get up very steep ramps.” Miranda says some surfaces, such as grass and gravel, has its own unique challenges for wheelchair users.

A few years coming
The SmartDrive devices are operated by a Bluetooth watch. By tapping twice on the chair or clapping twice, the motor propels the wheelchair forward and stops when tapped twice, while also braking with one’s hands. The speed can also be controlled by the user. The machines use rechargeable batteries, with a fully charged battery lasting up to 15 hours.

Acquiring the devices was a process of a few years, and CUADS is happy to finally employ them to the benefit of their students. Miranda says the determination and support of Prof Nicky Morgan, Vice-Rector: Operations, and the assistance of Nico Janse van Rensburg, Senior Director: Top Management, were instrumental in buying the devices.

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