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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Right to Learn cyclists cross the finish line

2017-12-05

The Right to Learn cycling team are happy and thankful that they have completed
their journey.
Photo: Mike Rose

After a seven-day journey, the Right to Learn cycling team have finally reached their destination. Having travelled for over a 1 000 kilometres from Bloemfontein, they arrived safely in the Paarl on Monday 4 December 2017. During their final stretch, they travelled 130 kilometres from Montagu to Paarl, where they ended the Right to Learn Cycling Tour.

Gratitude for support
Asive Dlanjwa, Bloemfontein Campus SRC President, says, “It's been good, it's been tough, and it’s been an amazing journey.” He expressed his gratitude to everyone who has been supporting them throughout the journey. “Thank you so much for every cent that you have given, for every prayer, and every thought.”

Thulasizwe Mxenge, one of the guest cyclists from Johannesburg, says, “Asive had informed us that most students struggle with access to higher education, and we saw the need to assist and take part in the initiative.” He says the journey was tough, because they had to cycle for about five hours every time they went on the road. “I’m very tired but also happy to have completed the journey.”

Donations received
Since the beginning of the Right to Learn initiative, they have managed to raise R80 000 through corporate giving, R15 584 on Dlanjwa’s GivenGain page, and $500 (about R6 845) from the GivenGain Foundation as part of the #GivingTuesday Twitter campaign which took place on 28 November 2017.

Annamia van den Heever, Director: Institutional Advancement, says, “Congratulations to Asive and the team! It has been an absolute pleasure to work with such positive and passionate young people.” She also thanked all donors to the Right to Learn campaign for their support, saying it will ensure that talented students who cannot afford university fees will have access to the UFS next year. “We are hoping that more people will donate now that the tour has been successfully completed. There is no better Christmas gift,” she says.

Dlanjwa says, “We are committed to helping learners who are coming to the UFS next year. The trip was amazing and I feel stronger than I expected. I’d definitely do this again.”
The community is still encouraged to donate towards the initiative, using the following details:

EFT transaction:
Please use the following bank details:
Bank: ABSA Bank
Account Number: 1570850721
Branch Code: 632005
Account Type: Cheque
Reference: R2L: Right to Learn
Send the proof of payment to Rinda Duraan: duraanmj@ufs.ac.za

Debit order: Download the form and email it to Rinda Duraan

All donations are tax deductible in terms of South African income tax legislation.

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