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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

IRSJ Research fellow embarks on historic ‘voyage’

2017-12-11

Prof John T Grider, making the maritime past alive again in the minds
of a new generation.
Photo: Eugene Seegers

Prof John Grider, Associate Professor of History at the University of Wisconsin-La Crosse in the USA and a Research Fellow in the Institute for Reconciliation and Social Justice (IRSJ) at the University of the Free State (UFS), has launched a book based on more than a decade of research into the Pacific maritime labour identity. His monograph, entitled A Foreign Voyage—Pacific Labour Identity, 1840-1890, delves into the history of the maritime industry, not only as a vehicle for expanding the processes of capitalism, colonialism, industrialisation, and globalisation, but is also exploring the impact of this industry on the shifts in gender, race, class, and technology.

As a student in Colorado, a homesick Grider tried to connect with his coastal roots via research. “Before I started to explore the maritime history, I thought of the ocean as a type of boundary that you sometimes need to cross. The truth is that globalisation happens on ships.” Prof Grider’s passion for Pacific maritime labour identity generates colourful discussions on the topic. Masculine sailors confronted by technological de-skilling that corroded away their identity, come to life as he talks and writes. “I try to show students that history is more than a story about the powerful few, and that everyday people, who may seem powerless, play a major role in shaping the past and the future.”

This monograph is based on first-hand, previously unpublished accounts of daily life at sea, often from ships’ logs and the diaries kept by the men who sailed them. The culmination of much painstaking research and supporting evidence, this book investigates the complex interplay between gender, class, and race sourced from the narratives of men who found themselves working in the transforming Pacific maritime industry during the mid-nineteenth century. A powerful lesson to be learnt from this fascinating segment of maritime labour history, is adaptability, “especially in today’s rapidly changing labour world”, Prof Grider says.

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