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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Fasset continues to fuel academic excellence at the UFS

2017-12-15

Programme Director: School of Accounting, Prof Hentie van Wyk, and
Dean: Economic and Management Sciences, Prof Hendri Kroukamp
excited about the unveiling of the Finance and Accounting Services
Sector Education and Training Authority (Fasset)
plaque at the School of Accounting.
Photo: Rulanzen Martin

The School of Accounting on the Bloemfontein Campus of the University of the Free State (UFS) held an unveiling ceremony for a Finance and Accounting Services Sector Education and Training Authority (Fasset) plaque. The plaque was unveiled by UFS Rector and Vice-Chancellor, Prof Francis Petersen, and Fasset CEO, Lesego Lebuso. This was in honour of Fasset’s partnership with the UFS and its contribution towards driving academic excellence through its Intrabas projects over the past few years.

Funding for teaching and learning initiatives
These projects support the development of black student enrolment and performance in Accounting Studies. During the previous year, Fasset gave the UFS R54 million in funding to support teaching and learning initiatives for 960 black Accounting students. These students were enrolled for BAcc, BCom(Acc), BAcc(Hons)/PGDipCA, and BCom(Hons in Acc)/PGDipGA studies. In the same year, a celebratory ceremony was held at the South Campus for 125 Fasset-funded students to celebrate their academic excellence.

Prof Hentie van Wyk, Programme Director: School of Accounting, said, “FASSET funding will give the Centre for Accounting (as it was then called) an opportunity to strengthen our current student-centred teaching model”. This seemed like a prophecy, because at the beginning of 2017, the class of 2016 BAccHons students achieved a 96% pass rate in the 2017 Initial Test of Competence (ITC) examinations of the South African Institute of Chartered Accountants (SAICA).

Millions contributed towards accounting degrees
In 2017, Fasset sponsored 114 students on the Bloemfontein Campus with full bursaries amounting to more than R20 million through the Intrabas bursary fund for degree qualifications in BAccHons, BComHons (Acc), BAcc, BComAcc and BComAcc Extended programmes, as well as the tutorial programme managed by the School of Accountancy. On the Qwaqwa Campus, Fasset has given more than R7 million worth of funding.

James Veitch, Senior Officer: School of Accounting, said, “A decision was made to rather fund less students so that they could be assisted with greater effect, and students who did not qualify for the bursaries, would still be assisted through the support programme.”

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