Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Sisulu Calls for Mugabe to go

2008-08-08

Human rights activist and renowned author, Ms Elinor Sisulu, has called on the president of Zimbabwe, Robert Mugabe, to step down.

Ms Sisulu made this call during her presentation of the Women’s Day lecture, titled: “Voiceless and voteless, fleeing zanuphobia into xenophobia: A Zimbabwean woman’s perspective of National Women’s Day” at the University of the Free State (UFS) on Wednesday.

She said thousands of Zimbabweans who fled their country because of violence will not return home unless Mugabe steps down.

“For the Zimbabweans in diaspora, what Mugabe symbolizes is so powerful that as long as he is there as a ceremonial president they will not return home. So the simple message from the South African office of the Crisis in Zimbabwe Coalition is that Mugabe must go”, she said.

She also lambasted the southern African region generally, and South Africa in particular, for its silence over what she calls “Zanu-PF orchestrated violence” that triggered the current refugee influx in the region.

“The South African government was totally silent on the loss of life of innocent and vulnerable Zimbabweans. The mediator said nothing about it”, she said in a clear reference to president Thabo Mbeki, the SADC-appointed mediator.

She said for the Zimbabweans who had to flee to South Africa it was a case of “jumping from the frying pan into the fire”, fleeing Zanuphobia to xenophobia”.

She, however, appealed to the South Africans to raise their voices about the refugee problem that is not only besetting this country, but the whole region.

Ms Sisulu was born in Zimbabwe and she works in the South African office for the Crisis in Zimbabwe Coalition, the major umbrella body of Zimbabwean non-gobernmental organizations.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
07 August 2008

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept