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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Unconditional accreditation for Architecture at the UFS

2008-08-20

The Department of Architecture at the University of the Free State (UFS) is so far the only department of its kind in the country to obtain unconditional accreditation from the South African Council for the Architecture Profession (SACAP) for all three its programmes.

“SACAP has already visited seven out of a possible ten institutions in the country who present Architecture. Of these, only the UFS’s Department of Architecture has so far received unconditional accreditation. This is indeed an achievement for us,” said Prof. Jan Smit, Head of the Department.

According to Prof. Smit, the SACAP’s evaluation of all institutions who offer Architecture takes place every four years. During the accreditation process in 2004, the department also received unconditional accreditation for the two programmes it presented at that stage, namely the B.A.S. degree and the B.Arch. degree. Since then, the B.Arch. degree has fallen away and the qualifications the department now offers are the B.A.S. degree, B.A.S. (Hons.) and the M.Arch.(Prof.).

“The unconditional accreditation serves as proof that the qualifications obtained by our students are of value and that it enjoys local and international recognition. It is also an indication that our students’ training is up to standard,” said Prof. Smit.

The criteria students are evaluated on includes the facilities, degrees and courses presented, the standard of exam papers and assignments of a subject, the style of management and staff compilation. The panel of judges comprise of among others a representative from the Commonwealth Association of Architects (CAA), who reports to the Royal Institute of British Architects (RIBA). “This is an indication of the high level on which the evaluation is being done,” said Prof. Smit.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
20 August 2008

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