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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Council wishes outgoing rector well

2008-09-05

Statement by Judge Faan Hancke, Chairperson of the UFS Council

The Council of the University of the Free State (UFS) hereby expresses its heartfelt thanks and appreciation to Prof. Frederick Fourie for his contribution to building and developing the UFS. His association with the UFS stretches over a period of 40 years – first as a student, later as a lecturer, dean, vice-rector and finally as rector and vice-chancellor.

When the University was operating at a loss during 2000 and it was in a financial crisis, he came up with a financial turn-around strategy which took the UFS out of this crisis to a position where it can annually spend considerable amounts on strategic projects. This led to large amounts being invested in the academia and especially research. As a result, the UFS’s research capacity and research equipment has been expanded. Since 2003 research outputs increased with about 50%, which is a great achievement for the UFS’s researchers and its faculties.

Progress was also made with diversity, the UFS’s balanced multilingualism policy in the academia as well as administration, employment equity, the transformation plan and the institutional charter. Under his leadership there was an upgrading and extension of the infrastructure, academic buildings and facilities as well as support services and student facilities.

Prof. Fourie has an excellent intellect and exceptional abilities which can still make a huge contribution to the improvement of the South African society. As a result of personal consideration and after 4 decades’ association with the UFS including 5 years in a leading position, Prof. Fourie decided to step down. The Council respects this decision and wishes him success and best wishes.

The process of appointing a new rector and vice-chancellor will follow the normal recruitment procedure of the UFS. In terms of this procedure a representative committee of Council, which includes all stakeholders of the UFS, will consider applications that are received.

Applications will be invited through an open and targeted process of recruitment advertising, locally, nationally and internationally to broaden the pool of applicants.

Within this process Council has expressed the view that applications from the designated groups in terms of Employment Equity must be encouraged.

It is also Council’s wish that this process be completed as soon as is possible, within the approved procedure.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
12 September 2008

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