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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

R12-million to train black chartered accountants

2008-10-09

The Centre for Accounting at the University of the Free State (UFS) will receive about R12-million over the next four years from the Thuthuka Bursary Fund to train black learners as chartered accountants.

The bursary fund is managed by the South African Institute of Chartered Accountants (SAICA) and is aimed at increasing the number of black students who obtain the Bachelor degree in Accounting.

Prof. Hentie van Wyk, Programme Director of the Centre for Accounting at the UFS, says that the membership of the chartered accounting profession (SAICA) does not currently reflect the demographics of the country. The aim of the bursary fund is to straighten this imbalance.

“The first intake of 50 first-year students is in 2009. The bursary fund makes provision for about R60 000 per student. This amount covers the student’s class fees, residence fees, meals and the financing of tutors. We will also make use of tutors and guest lecturers who will teach the students life skills, among others. The centre will appoint a co-ordinator to assist students with this,” says Prof. Van Wyk.

The UFS is accredited by SAICA to handle the Thuthuka training. During a monitoring visit from SAICA in 2007 the centre was the first in South Africa to obtain a 1-grading. The centre also obtained an outstanding pass rate of 94% during the recent national qualifying exam.

“We especially want to focus on the training of students from the central region. This means that the UFS will become a feeder institution of black chartered accountants for the business community in the central region of the country,” says Prof. Van Wyk.

According to Prof. Van Wyk, SAICA will do the recruitment of the students and they will be subject to a selection test. A list of possible students will be submitted to the centre, of which 50 will be chosen. One of the prerequisites is that learners must have a good mark in Mathematics. During their four years of studying students must have an average pass mark of 70%.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
9 October 2008

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