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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

First book on Bloemfontein published in 25 years

2008-10-21

During the launch of the book "Spatialities of Urban Change" are, from the left, front: Mr Malefetsane Mokoena, General Manager: Housing at the Mangaung Local Municipality and one of the co-authors of the book, Mr Amos Goliath, Executive Director: Corporate Affairs at the Mangaung Local Municipality, Ms Rothea van Biljon, Chairperson of the Afrikaanse Handelsinstituut Bloemfontein; back: Prof. Lochner Marais, editor of the book from the Centre for Development Support at the UFS, and Prof. Gustav Visser, editor of the book from the Department of Geography at the UFS. Photo Stephen Collett

The University of the Free State (UFS) has published a book on Bloemfontein for the first time in 25 years. The book, titled “Spatialities of Urban Change”, is the first South African scholarly account in book form of spatial themes on urban change in a secondary city in South Africa. The book was recently launched on the Main Campus in Bloemfontein.

The editors of the book are Prof. Lochner Marais from the Centre for Development Support and Prof. Gustav Visser from the Department of Geography, both from the UFS. Their co-authors are five Ph.D. students in Development Studies, one Ph.D. student in Geography and one master’s student in Development Studies.

According to Prof. Visser, there is a gap in the market for new perspectives on how cities work and how urban theory can develop. This book will contribute to filling that gap. The book also manages to involve students and their research – giving them the opportunity to have their research published.

The book addresses various aspects of Bloemfontein’s spatiality and issues such as suburbanization and the subsequent decline of the central business district, the city’s tourism potential and the impact of the Volksblad Arts Festival on re-imaging the city as a place that has something to offer any visitor, are discussed among others. Other topics include the suburb Westdene and how diverse spatiality manifests itself at this scale, and white flight from the inner city areas.

“A central theme running through the book is how the urban discourse of Bloemfontein relate to the country’s metropolitan core and conversely to other secondary cities,“ says Prof. Visser.

Media Release:
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
22 October 2008

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