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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Founding meeting of the Advisory Panel of the International Institute of Diversity
2008-11-21

The University of the Free State (UFS) today (20 November 2008) successfully convened and hosted the founding meeting of the Advisory Panel of the International Institute of Diversity.

In the wake of the Reitz video incident, the UFS wishes to establish an institute that will study and promote transformation on the campus as a microcosm of the much broader socio-political challenges facing South Africa. It is hoped that in due course the UFS and the institution will develop the expertise and experience to help other organisations and societies in transition.

The institute will work closely with the Transformation Cluster – one of six strategic academic clusters already created as part of the university’s long-term strategic plans.

Given the transformation climate in which it finds itself, the university recognises that the guidance, support and direct involvement of thought leaders and other specialists in the field of transformation are critical to the design and operation of the proposed institute. To this end, the university has established an advisory panel for the institute. The Advisory Panel will give guidance to the Executive Director (to be appointed) in helping with the conceptualisation, design, and development of the institute, and the compilation of its business plan.

Brian Gibson Issue Management facilitated the meeting and is also responsible for the reporting on the meeting. The International Institute for Development and Ethics (IIDE) co-hosted and provided the secretarial support for the meeting.

 


The members of the advisory panel:  

(Click here to read more about the Panel Members)

External panel members:

Dr Clint Le Bruyns, Senior Lecturer in Public Theology and Ethics at the University of Stellenbosch .

Dr Sebiletso Mokone-Matabane, Chief Executive Officer, Sentech Limited.

Dr Andries Odendaal works in the field of conflict transformation with international agencies such as the United Nations, DANIDA and GTZ.

Prof. Lungisile Ntsebeza, National Research Foundation (NRF) Research Chair in Land Reform and Democracy in South Africa in the Department of Sociology, University of Cape Town.

Mr Roger Crawford, Executive Director for Government Affairs and Policy South Africa, Johnson & Johnson.

Prof. Jonathan Jansen, Dean of the Faculty of Education, University of Pretoria 2001 to 2007.

Ms Zandile Mbele, Director of Plessey (PTY) Ltd. and the Transformation Executive for Dimension Data.

Dr André Keet, Director: Transdisciplinary Programme at the University of Fort Hare in October 2008 and part-time Commissioner with the Commission for Gender Equality.


Dr Reitumetse Obakeng Mabokela is an associate professor in the Higher, Adult, and Lifelong Education Program in the Department of Educational Administration at Michigan State University.

Dr Mpilo Pearl Sithole is a senior research specialist in the Democracy and Governance Research Programme at the Human Science Research Council.

Professor Steven Friedman, D.Litt. is Director of the Centre for the Study of Democracy at Rhodes University and the University of Johannesburg.

Representatives from UFS:

Prof. Teuns Verschoor, Vice-Rector: Academic Operations at the University of the Free State, and currently Acting Rector and Vice-Chancellor.

Prof. Piet Erasmus, Interim Co-ordinator for the Cluster Transformation in Highly Diverse Societies.

Prof. Lucius Botes, Director of the Centre of Development Support and Programme Director of the Postgraduate Programme in Development Studies.

Prof. Philip Nel, Former Director of the Centre for Africa Studies at the UFS.
 

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