Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Project aims to boost science pass rate

2009-01-19

Attending the launch of the HP grant of about R1 million to the UFS are, from the left: Mr Leon Erasmus, Country Manager for HP Technology Services in South Africa, Prof. Teuns Verschoor, Acting Rector of the UFS, and Mr Cobus van Breda, researcher at the UFS's Centre for Education Development and manager of the project.
Photo: Lacea Loader

The University of the Free State (UFS), in partnership with computer giant Hewlett Packard (HP), wants to boost the pass rate of its science students by using mobile technology.

The UFS is one of only 15 universities across Europe, the Middle East and Africa and the only university in South Africa to receive a grant from HP to promote mobile technology for teaching in higher education valued at USD$ 100,000 (or about R1 million). Altogether 80 universities from 28 countries applied for the grant.

“Last year HP invited a number of selected universities to submit proposals in which they had to explain how they are going to utilise mobile technologies in the redesign of a course that is presented at the university. The proposal of the Centre for Education Development (CED) at the UFS entitled “Understanding Physics through data logging” was accepted,” says Mr Cobus van Breda, researcher at CED and manager of the project.

According to Mr van Breda, students who do not meet the entrance requirements for the three-year B.Sc. programme have to enroll for the four-year curriculum with the first year actually preparing them for the three-year curriculum.

In order to increase the success rate of these students, the project envisages to enhance their understanding of science principles by utilising the advantages of personal computer (PC) tablet technology and other information and communication technologies (ICT) to support effective teaching and learning methodology.

“By using PC tablet technology in collaboration with data-logging software, a personal response system, the internet and other interactive ICT applications, an environment different from a traditional teaching milieu is created. This will consequently result in a different approach to addressing students’ learning issues,” says Mr van Breda.

The pilot project was launched during the fourth term of 2008 when 130 first-year B.Sc. students (of the four-year curriculum) did the practical component of the physics section of the Concepts in General Science (CGS) module by conducting experiments in a computerised laboratory, using data-logging software amongst other technology applications. “The pilot project delivered good results and students found the interactive application very helpful,” says Mr van Breda.

”The unique feature of the latter is the fact that real-life data can be collected with electronic sensors and instantly presented as computer graphs. It can then be analysed and interpreted immediately, thus more time can be devoted to actual Science principles and phenomena and less time on time-consuming data processing,” says Mr van Breda.

The CGS module can be seen as a prerequisite for further studies in physics at university level and in this regard it is of essence to keep looking for new models of learning and teaching which can result in student success. This year the theoretical and practical component of the physics section of the CGS programme will be done in an integrated manner.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
16 January 2009

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept