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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

A learning path for working adults

2009-02-09

From the left are: Ms Maquida du Preez (MDP Programme Manager), Ms Eliche Lorandi ( Marketing Executive), Mr Theo Potgieter (BEE and Transformation Manager), Ms Marie Griebenouw (Programme Manager) and Mr Danie Jacobs (Head: Centre fro Business Dynamics).
Photo: Mangaliso Radebe

In the short space of five years, the Centre for Business Dynamics at the University of the Free State (UFS) has grown in stature to such an extent that it is currently offering leadership development programmes at 45 institutions all over the country.

Speaking at the fifth anniversary of the centre’s establishment, its director, Mr Danie Jacobs, said the centre was the first commercial unit in South Africa, attached to a business school, to establish a desk focusing on Black Economic Empowerment (BEE) and Transformation in association with Empowerdex.

The main purpose of this joint venture with Empowerdex is to deliver comprehensive BEE training through the development and presentation of various programmes.

The centre has also introduced the High-Performing Directors’ Programme in association with ABSA. A total of about 40 students have enrolled for this programme so far,and their numbers fluctuate every year.

It is also the first unit in the country to link up with Thinking Fusion, one of the three consultancies contracted by the UFS, to introduce two unique leadership programmes, namely a programme in Creating Leadership and Personal Capacity in Women and the Leadership in the Connection Economy programme.

“Our aim is to prepare women for full participation as managers and leaders in transforming organizations to become truly integrated and representative of the full diversity spectrum of South Africa,” Mr Jacobs said.

“We have built amazing relationships with various clients, both in the private and public sector, over the last five years,” said Mr Jacobs. “I believe the success of the Centre for Business Dynamics lies within our methodology of action learning, as well as creating a learning path for working adults.”

“Because of our country’s history not all people are on an equal footing when it comes to prior learning, so we level the playing field by breaking the training up into easily absorbable components. The centre can address the training needs of any company because of the multiple resources that we are fortunate enough to have at our fingertips,” he said.

The centre also offers a Postgraduate Diploma in Tax Strategy and Management, aimed at bringing all parties involved in the field of taxation up to date with the latest developments and changes.

In addition, the centre has introduced The Choice and The Choice at Work programme in association with the Arbinger Institute in the United States of America. There are also two management programmes, namely the Management Preparation Programme and the Management Development Programme.

Apart from these programmes, the centre also offers products and services such as short courses, workshops and consultations.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
9 February 2009

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