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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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UV Voices Kamerkoor by die KKNK
2005-03-10

Membra Jesu nostri – Buxtehude (1637 – 1707)
 

Membra Jesu nostri patientis sanctissima (Die allerheilige liggaam van die lydende Jesus aan die kruis) deur Buxtehude het die Kruisiging van Jesus as tema.

Die uurlange werk word in Latyn gesing en handel in elk van die sewe dele oor ‘n deel van Jesus se liggaam aan die kruis: voete, knië, hande, die sy, bolyf, hart en gesig. Voices Inc – Kovsie kamerkoor word bygestaan deur die Odeion Strykkwartet met Francois Henkins, Abrie de Wet, John Wille en Michaela Haller. Die kontrabas word deur Alba Henkins-Molller bespeel en Jan Beukes is die orrelis.

Die woorde in Latyn wat buitengewoon was vir ‘n werk deur Buxtehude, is geneem uit die Latynse Bybel (Vulgate) en van die Rhytmica Oratio Sancti Bernadi, ‘n strofiese gedig deur St Bernard van Claivaux (c1090 – 1153).

Die wyse waarop Jesus se pyn aan die kruis uitgebeeld word asook die gebed en uitroep van versoening tussen God en die mensdom was deel van die Piëtiste se oortuigings van die tyd.

Die werk is saamgestel uit sewe afsonderlike dele wat telkens deur ‘n instrumentale sonate aangekondig word. Die koor lui die vokale bydrae in en sluit elke deel ook af. Die res van die werk bestaan uit verskillende groeperings van solo’s en trio’. Interessante vokale kombinasies kan gehoor word, bv. twee soprane en bas asook sopraan, alt en tenoor.

Hierdie opwindende aanbieding van Membra Jesu nostri, ‘n juweel uit die Baroktydperk, word aangebied deur ‘n groep energieke studente van Kovsies. Die jeugdige klank van die soliste – almal studente aan die Universiteit van die Vrystaat - dra by tot die egtheid van die Barok-klank. Die koor staan onder leiding van Leona Geldenhuys, dosent in Koorleiding aan die UV.

Optreedatums in die Moederkerk op Oudtshoorn. is:

 

  • Vrydag 25 Maart om 19:00
  • Saterdag 26 Maart om 13:00
  • Sondag 27 Maart om 19:00
  • Maandag 28 Maart om 16:00
  • Dinsdag 29 Maart om 10:00

Toegang is R50,00

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