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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

New head for Student Academic Services

2009-03-05

The University of the Free State (UFS) has appointed Mr Frank Madimetja Nkoana, pictured, as the new Director of Student Academic Services (SAS).

Mr Nkoana has a wealth of experience having worked for 24 years in the field of academic administration, 14 of which have been in leadership and senior management positions, at various institutions of higher learning.

In this post he will supervise applications, admissions, financial aid and registrations through to graduations.

The Director: Student Academic Services has a pivotal role to play in developing and supporting the University’s educational agenda.

“I consider my appointment to the Division as the correct one at the right time and a blessing to the UFS in view of my experience and training in the field of academic administration,” he said.

He believes it is only through effective and efficient academic support services that the institution can achieve excellence in its academic endeavour in tandem with its vision of being “an excellent, equitable and innovative University”.

“I must see to it that SAS, as both a sector and a process, is sufficiently and appropriately supported and maintained through an effective administrative structure that is manned by skilled and well-trained personnel, adding thereto continuous development and job enhancement – thus creating a conducive environment for efficiency and effective service delivery to students, staff and the wider community,” he said.

However, he is also mindful of the challenges facing him and the Division. He considers as his main challenge, among others, the creation of a Division that is functionally able and has as its goal the achievement and provision of effective academic administrative support to the core university business.

“Our operations should be in line with new developments in academic administrative systems to enable the UFS to achieve academic excellence and global competitiveness,” said Mr Nkoana.

“We must be able to establish and strengthen a high level of ethos of service delivery and develop good human relations between the staff and the students.”

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
05 March 2009

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