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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS appoints Jansen as rector
2009-03-15

The Council of the University of the Free State (UFS) is pleased to announce that it has agreed to offer the post of Rector and Vice-Chancellor of the UFS to internationally renowned academic Prof. Jonathan Jansen, making him the first black Rector and Vice-Chancellor of the institution in its 105-year history.

This decision was taken by an overwhelming majority, signalling the commitment of the UFS to continue as a world-class university that will at the same time pursue the objective of transformation in the interests of the entire university community.

Announcing the decision today (Friday, 13 March 2009), the Chairperson of the UFS Council Judge Faan Hancke said the UFS was privileged to have had candidates of the highest calibre apply for the position. An international executive search agency specialising in academic appointments had assisted the UFS Council in its search for top quality candidates.

“This has been a truly vibrant, transparent and participatory selection process, which has resulted in our institution being able to make this historic appointment,” said Judge Hancke.

“I appeal to the entire UFS community, staff, students and alumni to support the new Rector and Vice-Chancellor in his endeavour to lead this institution to greater heights. This is an important moment in the life our institution. We should celebrate this achievement as a united university community,” Judge Hancke said.

“As a council we are now unanimously behind Prof. Jansen and want to assure him of our full support,” Judge Hancke said.

In response to his appointment, Prof. Jansen said it was a great privilege and that he would really do his utmost best to be of service to the UFS.

In his statement of intent which was submitted earlier as part of his application for the post, Prof. Jansen indicated that if appointed he “would be deeply honoured to lead one of South Africa’s great universities”.

“The University of the Free State has gained a national reputation for three things: [1] its turnaround strategy in terms of financial stability in a context where external funding has been uncertain; [2] its research strategy which has seen a steady and impressive growth in research outputs; and [3] its managerial decisiveness in the wake of the Reitz incident,” Prof. Jansen said.

Regarding the challenges facing the UFS, Prof. Jansen said in his statement of intent: “The UFS has to find a way of integrating classroom life while at the same time ensuring the promotion of Afrikaans, an important cultural trust of the institution, as well as Sesotho and other indigenous languages. It has to bring academic staff, administrative staff, workers, students, as well as the parent community behind a compelling vision of transformation that works in the interest of all members of the university community. And it has to rebuild trust and confidence among students and staff in the mission of the university.”

Prof. Jansen is a recent Fulbright Scholar to Stanford University (2007-2008), former Dean of Education at the University of Pretoria (2001-2007), and Honorary Doctor of Education from the University of Edinburgh. He is a former high school Biology teacher and achieved his undergraduate education at the University of the Western Cape (BSc), his teaching credentials at UNISA (HED, BEd) and his postgraduate education in the USA (MS, Cornell; PhD, Stanford).

He is also Honorary Professor of Education at the University of the Witwatersrand and Visiting Fellow at the National Research Foundation.

His most recent books are Knowledge in the Blood (2009, Stanford University Press) and his co-authored Diversity High: Class, Color, Character and Culture in a South African High School (2008, University Press of America). In these and related works, he examines how education leaders balance the dual imperatives of reparation and reconciliation in their leadership practice.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
13 March 2009
 

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