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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Department celebrates 50th anniversary

2009-03-25

The first Departmental Head and the subsequent Departmental Chairpersons at the dinner on 14 March this year. From left: Proff Bernard Prior (1991-1998), Piet Lategan (1962-1990), Derek Litthauer (1998-2002) and James du Preez (2002-). These are all the Heads/Chairpersons of the Department since its founding in 1959, with the exception of Prof Hans Potgieter who acted as Head during 1959-1962.
Photo: Stephen Collett

Department celebrates 50th anniversary

On 13 March the Department Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS) celebrated its 50th anniversary in a splendid fashion with a lecture entitled, The origin of life: Exactly how did life begin? as part of the Darwin commemorative lecture series, followed by a reunion of current and former staff members and postgraduate students of the department with a barbeque on the following day.

The proceedings were concluded on 14 March with a gala dinner in die Centenary Complex at the UFS attended by 153 staff members, post-graduate students (current and former) and other guests. During the dinner the guests were treated to a presentation of historical photos of the founding and development of the department. Currently the department is one of the largest departments in the Faculty of Natural and Agricultural Sciences in respect of the number of staff members and students as well as research outputs. This is the result of entrepreneurial actions to increase student numbers and research activities, as well as the merging with the smaller Department of Biochemistry in 1988 and more recently with the Department of Food Science in 2002. The department comprises 20 academics, 24 support staff and 65 postgraduate students. It also boasts 12 lecturers with ratings from the National Research Foundation (NRF), which include three academics with a B-rating, an indication of international recognition for their research. The department has the largest number of lecturers with an NRF-rating at the UFS.

“It was interesting to learn during the reunion of the variety of professions occupied by former students of the department, i.e. at other tertiary educational institutions, the CSSIR, SAPPI, Sasol and a multitude of other industries, as well as at research institutions in the USA and Australia,” said Prof. James du Preez, Head of the Department.

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