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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Government to benefit from training of interpreters

2009-03-31

Pictured, from the left, are: Prof Theo du Plessis (Director: Unit for Language Management, UFS), Ms Mokone Nthongoa (HOD: Sport, FS Department of Sport, Arts and Culture), Mr Khotso Sesele (MEC: FS Department of Sport, Arts and Culture) and Prof Engela Pretorius (Vice Dean: Faculty of the Humanities, UFS).
Photo: Mangaliso Radebe

Government to benefit from training of interpreters

The fourth phase of a project to train eight conference interpreters and 30 community interpreters to assist government departments at service delivery points in the Free State was launched this week.

The project is part of the Multilingualism Information Development Programme which brings together the Free State provincial government, the Province of Antwerp and the University of Antwerp in Belgium and the University of the Free State (UFS).

Speaking at the launch of the fourth phase of the project, the MEC for Sport, Arts and Culture in the Free State, Mr Khotso Sesele, said: “The fact that we have been through the first three stages of this project, and are now launching its fourth phase, is indicative of the magnificent progress that has been made. This is a sign that through partnerships we can achieve more.”

The MIDP IV consists of two pillars, namely a practical and a research component. Its aim is to generate interpreting capacity within the provincial Department of Sport, Arts and Culture. The focus is on training an interpreting team over three years which can be employed within a governmental context at various service points.

“As we approach the 2009 FIFA Confederation Cup and the 2010 FIFA World Cup tournaments, it will be important for our communities to be able to interact with millions of foreign nationals who will be in our country from different world destinations during and beyond these two important soccer events,” said the MEC.

“The focus on interpreter training by this fourth phase of MIDP is thus an important factor in ensuring better communication during and beyond these important soccer spectacles that will take place in our country.”
The focus of the first three phases of the MIDP was on the main official languages of the province. This fourth phase, which started in 2008, will run until 2010 and its focus is on the Xhariep District Municipality.

“The provision of interpreting services and its further extension to district municipalities will provide the necessary interpreting skills to our communities that will enhance better interaction amongst ourselves,” said Mr Sesele.

He said the fact that indigenous languages have been “elevated from their marginalised status to being languages of business and commerce” is an important milestone that must be cherished.

This fourth phase of MIDP will also incorporate sign language as part of its focus on interpreting services.

“In our quest to ensure a multilingual dispensation in our province, we need not neglect to remember people with disabilities,” he said. “This is a matter of principle that does not require debate.”

“We should thus ensure the realisation of the goal of MIDP IV which is to ensure smooth communication interaction within the wider public, including the deaf community.”

“This is a wonderful project,” said Ms Mathabo Monaheng, one of the students in the MIDP. “As a sign language interpreter trainee this project will empower me with the necessary skills to be able to make a meaningful contribution to the deaf community in terms of communication.”

The MIDP is funded by the Province of Antwerp and successfully implemented by the Unit for Language Management at the UFS.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
31 March 2009

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