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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

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The management teams of the University of the Free State and the Vista University Bloemfontein campus set the wheels rolling for the incorporation of

2003-05-22

The management teams of the University of the Free State and the Vista University Bloemfontein campus set the wheels rolling for the incorporation of the Vista Bloemfontein campus into the UFS.

The incorporation process will be dealt with in two phases. The first phase would be preparing for a possible incorporation on 1 January 2004, including possible streamlining and review of programmes. The second phase would be part of developing the long term vision or optimal reconfiguration of the Vista facility (within the UFS as a multi-campus institution) in the interests of higher education in the Free State and the communities surrounding the two campuses in Bloemfontein.

At a meeting at the UFS both parties reached consensus about the process and set about establishing task teams to deal with critical issues, such as governance and management, financial management, human resources, information systems, library services, student support and administration, academic planning and academic programmes.

Prof Talvin Schultz, Head of the Vista Bloemfontein campus, committed this campus to making the process of incorporation into the UFS an exemplary process. UFS Rector Prof Frederick Fourie said the Free State should continue its tradition as a province where things happen and where higher education transformation has proceeded faster than elsewhere in the country.

Both emphasised the need for an inclusive process of consultation with staff, students and the community on key aspects of the incorporation.

They indicated that all planning should take into account a possible date of incorporation of 1 January 2004, pending finalisation by the respective Councils. The Councils of both institutions need to give feedback to the Minister of Education on the date of incorporation by the end of June, and the task teams must deliver an initial report on progress before then.

Prof Talvin Schultz (Vista Bloemfontein campus) and Prof Frederick Fourie (UFS)

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