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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Science school of excellence for Grade 11 learners launched
2009-04-21

 
At the launch of the Science School of Excellence were, from the left: Prof. Neil Heideman, Vice-Dean: Faculty of Natural and Agricultural Sciences at the UFS, Mr John Davids, General Manager, Volksblad, Ms Lorraine Botha, Chief Professional Officer, Centre for Education Development at the UFS, and Rev Kiepie Jaftha, Chief Director: Community Service at the UFS.
Photo: Dalene Harris

Science school of excellence for Grade 11 learners launched

The Faculty of Natural and Agricultural Sciences at the University of the Free State (UFS) has launched a project to give top Grade 11 learners an idea of what the faculty has to offer by giving them a ‘university-type’ experience.

The Science School of Excellence Project was launched last week during a function where the university’s schools support programmes were introduced to the management and members of staff.

The project is aimed at Grade 11 learners in the Free State who obtained an overall average of 80% in the 2008 Grade 10 final examinations. This includes a minimum score of 80% (Level 7) in Mathematics and a minimum score of 80% (Level 7) in Physical or Life Science during the same examination. It will be presented on the Main Campus in Bloemfontein from 6-9 July 2009. The closing date for applications is 8 May 2009.

“By presenting this project we want to stimulate learners’ interest in the natural and agricultural sciences, give them an idea of what we have to offer, raise their interest to come and study at the UFS and let them know that we cherish them as role models in their schools and as academic leaders of the future,” said Prof. Neil Heideman, Vice-Dean of the Faculty of Natural and Agricultural Sciences at the UFS.

According to Prof. Heideman the Science School of Excellence will take on the form of small lab and field projects which the learners will carry out under the supervision of staff and postgraduate students. An application fee of R50 per learner must be paid by the school and a maximum of 80 learners can be accommodated. The 80 learners will be selected on a first come, first served basis and a registration fee of R200 per learner has to be paid after they have received notice that they have been accepted. Letters in this regard have been sent to principals of secondary schools in the Free State. “We will also include 10 learners from disadvantaged rural schools, who will be fully sponsored,” said Prof. Heideman.

“Fourteen of our departments will be presenting programmes, during which learners will engage in challenging exercises that will be ‘out of school’ experiences involving laboratory experiments and research activities typical of our faculty,” said Prof. Heideman.

Five other schools support programmes of the UFS were also presented during last week’s launch function. They were the Itjhoriseng Project, which is a skills development course in Mathematics and Physical Sciences for teachers in the Further Education phase; the Science for the Future Project that aims to encourage more learners to enter into science-related studies and careers; the Qwaqwa School Support Programme that aims to improve the year-end results of Grade 12 learners and a project by the South African Foundation for Economic and Financial Education (SAFEFE) and the National Council of Economic Education (NCEE),which aims to improve the economic and financial literacy of teachers.

“The university’s role in the development of teachers and learners in various subject fields has increased tremendously over the past couple of years. Learners are our students of the future. As a university we must do as much as we can to equip them and their teachers with the necessary skills to better themselves,” said Rev. Kiepie Jaftha, Chief Director: Community Service at the UFS at the launch of the Science Schools for Excellence Project.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
20 April 2009

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