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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

CD-ROM for learning Afrikaans as foreign language launched

2009-04-30

At the launch of the CD-Rom, Gesellig Afrikaans, are from the left: Ms Riana de Beer, Research Assistant at the Department of Afrikaans and Dutch, German and French, Mr Christo Steyn from Bare Creative who did the digitalisation of the CD-ROM, Prof. Van Niekerk, Prof. Engela Pretorius, Vice-Dean of the Faculty of the Humanities, Prof. Driekie Hay, Vice-Rector: Academic Planning, and Mr François Marais, Director of the Centre for Higher Education Studies and Development at the UFS.
Photo: Lacea Loader

The Department of Afrikaans and Dutch, German and French at the University of the Free State (UFS) recently launched a CD-ROM course to learn Afrikaans as foreign language at the Main Campus in Bloemfontein.

For the past ten years the Department has been offering a course in Afrikaans as foreign language to small groups at the UFS. “However, the need for this course has escalated to such an extent on the Main and Qwaqwa Campuses of the UFS that we have decided to produce the CD-ROM. We have also found that not a lot of courses to learn Afrikaans were available. Those that do exist, do not recognise the needs of adult learners,” said Prof. Angelique van Niekerk from the Department.

“International students are often interested in learning new cultures and languages and staff members would also like to learn Afrikaans in order to understand the language better. Now they are able to master the basic principles and concepts of the language,” said Prof. Van Niekerk.

The course, which will be presented on the Main Campus, comprises a basic and an advanced course. Course attendants will receive both these CD-ROMs. English is used as the back-up language and translations of all the texts are available on the CD. Contemporary Afrikaans music is used to assist in fixing sound patterns, and the pronunciation of Afrikaans sounds, words and sentences is available through the sound component of the course. Uncomplicated language jokes, advertisement texts and cartoons are used to enhance the course content and a vocabulary list and list of idiomatic language uses will be kept updated by the learners. Explanations of basic grammatical constructions are given in both Afrikaans and English and learners are assessed at the end of the course. Aspects like word order, temporal indications, etc. are covered amongst other things.

“Mastering a foreign language is time-consuming and contact with the language is very important. Although there is a contact session with a facilitator of two hours per week, it is a handy course for people who cannot attend classes regularly,” said Prof. Van Niekerk.

The CD-ROM is available from at Prof. Angelique van Niekerk, vnieka.hum@ufs.ac.za, Tel. no. 051-4012339, at R150 per CD.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
28 April 2009

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