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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Sport results: Tennis, Netball, badminton, athletics

2009-05-05

During the Mega-intervarsity Tournament held at Sun City last week, both the University of the Free State’s (UFS) men’s and women’s tennis teams beat their opponents. The Kovsies women’s team beat the Pukke 15-0, Tukkies 15-1 and Maties 12-5. The Kovsies men’s team beat their respective opponents as follows: Maties A 12-6, Maties B 15-0, Pukke A 9-7, Tukkies A 14-1 and Pukke B 15-0. Janine de Kock from KovsieSport said that she was satisfied with these achievements. “For the past two years the women have won the University Sports South Africa (USSA) tournament and now again this tournament. What makes this achievement special is the fact that it was the first tournament that four of the women’s team members played for the UFS.” “I am also very satisfied with the achievements of the men’s team. They ended sixth in last year’s USSA tournament. This year, at a tournament where the top four universities in terms of tennis were present, they won,” said Janine.
	Rensia Henning in action during the Mega-intervarsity Tournament that took place at Sun City last week. Photos: Jeanine de Kok
Netball: Hard work gets rewarded - (April 2009) Three Kovsies were selected from the South African National Netball team to the Senior Top 12 Team that will represent South Africa at the SPAR Challenge, a three nation’s test series against Botswana and Fiji. These matches will take place towards the end of May in Pretoria. The three students are Elzet Engelbrecht, Maryka Holtzhausen, en Adele Niemand. Kovsie students compete at badminton championships One former student from the University of the Free State (UFS) Chris Dednam, and one current Kovsie student Annari Viljoen are included in the National Badminton Team that represented South Africa from 17 to 24 April 2009 at the All Africa Badminton Championships in Nairobi, Kenya. They also participated in the Kenya International Championships from 25 to 27 April 2009. Chris Dednam and Annari Viljoen and with them Roelof Dednam, also a former Kovsie student, were included in the team that will participate at the Sudirman Cup in Guangzhou, China. The Sudirman Cup that will take place from 10 to 17 May 2009 is the world mixed team badminton championship and takes place every two years. Kovsie athletes win medals Kovsie athletes excelled at the South African Students Athletics Championships (USSA) that was held in Stellenbosch by winning a total of 15 medals. The medal winners are: Gold: Thuso Mpuang for the 200m, Johan Cronjè for the 1 500m, Maryna Swanepoel for the half marathon and Marizette Badenhorst for hammer throw. Silver: Thuso Mpuang for the 100m, Johan Cronjè for the 5 000m, Charles le Roux for triple jump, Ronè Reynecke for the 800m, and Abongile Lerotholi for 1 500m. Bronze: Kagisho Kumbane for 100m and 200m, Boy Soke for half marathon, Charles le Roux for long jump, Thandi Malindi for the 3 000m steeple chase, and Marike Steyn for triple jump. In the team competition the Kovsie men’s team received third place and the women’s team fourth place.

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