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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New electoral body for student elections
2004-07-24

The University of the Free State (UFS) has appointed the Electoral Institute of Southern Africa (EISA) to handle the upcoming election of the Student Representative Council (SRC) and Student Parliament on the main campus.

"EISA specialises in elections and have done vast research on the subject"said Dr Natie Luyt, acting Dean: Student Affairs at the UFS.

Dr Luyt said that the UFS wanted an electoral body that can act as neutral and objective as possible. "EISA is a credible electoral body with the necessary knowledge and expertise. We have full confidence that they will ensure a free and fair election on campus"said Dr Luyt.

"EISA is a neutral party and our main aim is to promote democracy through the process of elections"said Mr Seth Phamuli, Chief Electoral Officer of EISA's UFS election campaign.

Mr Phamuli said that EISA has handled the SRC and Council elections of several other tertiary institutions in the country. These include among others the University of the Witwatersrand , the University of the North, Unitra, Wits Technicon, Vista and Pretoria Technicon. "EISA also acts as the secretariat for the Southern African Developing Countries (SADC) as far as elections are concerned and manages the election processes of various parastatal bodies in the country"said Mr Phamuli.

No changes to the constitution of the SRC have been made for this year's election. "The UFS Council decided last year that any changes to the constitution of the SRC should be submitted for consideration by the Council meeting which took place in June. However, the amendments were submitted late - after the closing date for agenda items to be added"said Dr Luyt.

The elections on the main campus will take place on 11 August 2004 .


MEDIA RELEASE
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za 25 Julie 2004

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