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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Students get practical training in banking

2009-05-13

At the official announcement of the ABSA Internship Programme were, from the left: Ms Venete Klein, Executive Director: ABSA Retail Banking, Prof. Helena van Zyl, Director of the School of Management at the UFS, and Ms Christa de Bruin, Programme Leader: Internships at ABSA; back: Tebogo Mekgwe and Chantelle de Coning. Both are Honours students in Financial Economics and Investment Management at the UFS.
Photo: Stephen Collett

The Faculty of Economic and Management Sciences at the University of the Free State (UFS) has launched a unique programme that will give provide postgraduate B.Com. students with the opportunity to work at the ABSA Regional Office in Bloemfontein for three weeks and obtain practical experience on what banking entails.

“It is the first time in the history of our faculty that we are getting involved with a programme of this nature where theory and practice will meet,” said Prof. Helena van Zyl, Director of the School of Management at the UFS at the official announcement of the ABSA Internship Programme this week.

The ABSA Internship Programme was born out of the faculty’s long-standing relationship with ABSA. The programme, the brain child of Mr Deon Loots, former Regional Manager of ABSA in the Free State, offers the ten hand-picked students the opportunity to equip and empower themselves better for their future. They will be working at the ABSA Regional Office from 22 June to 10 July 2009 and will be exposed to as many focus areas of the bank as possible in order to give them a good overview of what banking entails.

“A degree, even an honours degree, is not enough. When graduates knock on an employer’s door he/she already assumes that the student will have a certain set of knowledge. We must once again look at ways to enhance our students’ practical and softer skills in order for them to compete in the labour market,” said Prof. Van Zyl.

“With this programme we want to equip and empower our students and develop their talents. In the end the student must be able to answer the question, “What makes me better than the 27 000 other students on our campus and on campuses elsewhere?” Prof. Van Zyl said.

Ms Venete Klein, Executive Director: ABSA Retail Banking and Visiting Professor at the University’s School of Management stated that it was always good to meet and engage with young talent, the leaders of tomorrow. “The students are entering the world of work at a crucial and difficult stage; a time when financial services worldwide are transformed. They have proven themselves academically. Now they have the opportunity to complement theory with work experience. With this programme they can develop into competent and compassionate professionals. I am proud that ABSA is part of this programme,” she said.

Media Release:
Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
13 May 2009

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