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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Department Old Testament receives visiting professor from the USA

2009-05-19

Prof. Fanie Snyman (left) and Prof. Leder.

Prof. Arie Leder, professor in Old Testament at the Calvin Theological Seminary, Grand Rapids, Michigan in the United States of America (USA) set foot on the African continent for the first time when he visited Prof. Fanie Snyman of the Department Old Testament in the Faculty of Theology at the University of the Free State (UFS). Prof. Leder is a visiting professor at the Department of Old Testament.

During his two-week-long visit to the faculty he amongst others lectured to undergraduate and master’s students. The lectures addressed issues related to the first five books of the Old Testament with the focus on the interpretation of the Hebrew text. The mentioned historical books of the Old Testament were discussed with the postgraduate students of the faculty. During the meeting of the Discussion Group for Biblical Sciences, Prof. Leder presented a public lecture with the theme, “Lady Wisdom and Sir Folly: Preaching Esther for such a time as this”.

According to Prof. Snyman, the agreement with Prof. Leder was to present the same lectures as what he would have delivered at the Calvin Theological Seminary. “The aim was to compare the standards, course content and presentations of the lectures that are presented by the respective departments, with each other. We compare well with the Calvin Theological Seminary and we do not have to be ashamed of ourselves. The feedback of the students about the exposure to another lecturer from another institution was also positive,” said Prof. Snyman.

The possibility of future collaboration was also discussed, specifically with the objective of both institutions publishing articles in the respective journals of both institutions. A further positive result of Prof. Leder’s visit is that colleagues of the Calvin Theological Seminary will be approached to act as external examiners for postgraduate students,” said Prof. Snyman.

The Calvin Theological Seminary libraries are some of the best equipped theological libraries in the world and as a result of the collaboration between our two institutions, staff of this faculty will get the opportunity to visit the Calvin Institution and to utilise the facility.

Photo: Leonie Bolleurs

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