Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Exciting Science School of Excellence for Grade 11 learners presented
2009-05-21

The Faculty of Natural and Agricultural Sciences at the University of the Free State (UFS) is presenting a Science School of Excellence for top achievers in Grade 11 from 6-9 July 2009. This will take place on the Main Campus in Bloemfontein.

Four exciting days are planned during which Grade 11 learners will participate in challenging extra-curricular exercises as well as laboratory and research activities. All classes will be presented in English and Afrikaans.

A maximum of 80 learners can be accommodated and selection will take place on the basis of first come, first accepted. An application fee of R50,00 per learner is payable.

The closing date for applications is 29 May 2009. The successful candidate will be notified telephonically. A further registration fee of R200,00 is payable by the successful learners. Learners are responsible for their own transport and accommodation. The registration fee includes all meals, lectures and activities.

In order to qualify for the UFS Science School, learners had to achieve an average of 80% [level 7] during the 2008 Grade 10 final examinations. They also had to obtain a minimum of 80% [level 7] in Mathematics and Physical or Life Sciences during the same examination. Learners who are interested in the Department of Computer Sciences and Informatics will also need Grade 10 CAT at level 7. A certified copy of the learner’s school report must accompany the application form.

“Our vision is to make the Faculty the preferred choice in central South-Africa for those who wish to pursue their studies in the natural and agricultural sciences,” said Prof. Neil Heideman, Vice-Dean of the faculty.

For application forms and enquiries, please contact the coordinator, Mr Johan Kruger, at 051 401 3199.

Media Release
Issued by: Lacea Loader
Assistant Director: Media liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
20 May 2009

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept