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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Community engagement must be a core function of universities

2009-05-21

Members of the NatCEMF Steering Committee are, from the left: Mr Jerome Slamat, Senior Director: Community Interaction, Stellenbosch University, Ms Beatrix Bouwman, Manager: Community Engagement, North-West University, Rev Kiepie Jaftha, Chief Director: Community Service, UFS and chairperson of the committee, Prof. Allan Femi Lana, Director: Institute for Rural Development and Community Engagement, Mangosuthu University of Technology, Prof. Seth Pollack, Fulbright Scholar, University of Western Cape (guest speaker at the meeting), Prof. Denver Hendricks, Director: Community Engagement, University of Pretoria, and Prof. Priscilla Daniels, Chairperson: Human Ecology and Research and CHESP Research Coordinator, University of the Western Cape.
Photo: Lacea Loader

It is important that all tertiary institutions in South Africa should work together and commit themselves to advance the cause of community engagement in the country.

This was one of the main outcomes of the second meeting held by the National Community Engagement Manager’s Forum (NatCEMF) at the South Campus of the University of the Free State (UFS) in Bloemfontein recently. The meeting was attended by 34 representatives of 16 higher education institutions in the country.

“I am astounded at the interest in this matter. The representatives are committed to make community engagement a core function of their institutions and we all agreed that we should get more involved in expanding this across all institutions. A need for a formal structure for us all to work together and have a more collective voice was also identified,” said Rev Kiepie Jaftha, Chief Director: Community Service at the UFS and Chairperson of the NatCEMF Steering Committee.

“There is a growing need to expand and develop our engagement with communities – to share our experiences and best practices and to learn from each other. There are universities that are doing excellent work in this field and, by having a formal structure, we can do a lot more towards advancing community engagement,” said Rev Jaftha.

The meeting identified matters such as the coordination of higher education institutions’ involvement in community engagement, the facilitation of research about community engagement, promoting service learning as transformation, the establishment of a community engagement resource centre and the organisation of a national community engagement conference as some of its aims. A national steering committee was also elected.

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