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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Kovsie student represents SA at Sudirman Cup in China
2009-05-26

The South African National Badminton Team recently represented South Africa at the Sudirman Cup in Guangzhou, China. The Sudirman Cup is the World Mixed-team Badminton Championships, which take place every two years.

Annari Viljoen, a Kovsie student and the brothers Chris and Roelof Dednam, former Kovsie students, were included in team that represented South Africa at the championships.

In the first match of the tournament, the Dednam brothers were the only victors when they won the mens doubles and defeated Paul Jefferson Vivas and Ronel Estanislao of the Philippines with 2117 and 2112.

In their second match, the South African team beat Luxembourg 41. In the mixed doubles the Dednams defeated Joe Michels and Yann Mellers with 2111 and 219 and in the womens doubles Michelle Edwards and Annari beat their opponents Anne Schumacher and Annick Weides with 1321 and 2224.

The South African team competed against Turkey in their third match and won 32, only losing the singles event. In the mens doubles the Dednams defeated Mehmet Tural and Ali Kaya with 2116 and 2113 and in the womens doubles Michelle Edwards and Annari beat Derya Calimbay and Oznur Caliskan with 2220 and 2117.

In the final group match team South Africa competed against Switzerland and lost 41 with only the mixed doubles pair of Dorian James and Annari winning their match against Anthony Dumartheray and Sabrina Jacquet with 1221, 2422 and 2119.

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