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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS council approves guidelines for reconfiguration of Vista Campus

2005-03-15

Human resource development (teaching and training) will be the primary aim of services to be rendered at the reconfigured Vista campus of the University of the Free State (UFS).

This in-principle decision forms part of a set of guidelines for the strategic reconfiguration of the Vista campus in Bloemfontein that was recently approved by the UFS Council. The Vista campus was incorporated into the UFS in January 2004.

“One of the most important aspects that resulted from these guidelines is that we have come to a point where I can say that the future of staff at Vista is not dependant on the strategic reconfiguration of the campus. Vista staff members will stay staff of the UFS and are being integrated into the functions of the main campus,” said Prof Magda Fourie, Vice-Rector: Academic Planning at the UFS.

“According to the guidelines, the reconfiguration of the Vista campus must occur within the ambit of the UFS as a single institution with three campuses,” said Prof Fourie.

The UFS is currently offering two activities on the Vista campus – the regional Centre for Recognition of Prior Learning (RPL) and the Sesotho Language Research and Development Centre.

According to Prof Fourie no duplication of services or programmes being rendered on the main campus in Bloemfontein will take place. In the guidelines suggestions are made that the Vista campus could be used for activities that are currently offered on the main campus (eg short learning programmes), new UFS activities (mainly of a developmental and entrepreneurial nature), cooperative partnership ventures with other role-players and the renting of facilities for education and training purposes.

“However, no definite decisions have been made about these possible activities – the necessary consultation process with relevant stakeholders and role-players must first take place. A consultative forum for this will be established early in the second term of this year,” said Prof Fourie.

“We are excited about the possibilities that have arised from the guidelines as it fits in with our vision to utilise new resources for education and training and to contribute to higher education in the Free State. This will also contribute to the development of human resources as a propelling force in the Central Region,” said Prof Fourie.

MEDIA RELEASE
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
15 March 2005

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