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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

DiMTEC hosts second conference on disaster risk reduction

2009-06-02

Dr Anthony Turton, the Director: TouchStone Resources (Pty) Ltd. delivered the opening address at this year’s two-day annual international conference on disaster risk reduction that was presented by the Disaster Management Training and Education Centre for Africa (DiMTEC) at the University of the Free State (UFS).

In his presentation: Sitting on the horns of a dilemma: South Africa and its strategic water supply, he said: “We have simply reached the limit of the water resources in South Africa. On the one hand, we deal with the quantity dilemma in terms of strategic water storage. South Africa and Zimbabwe counts under the top 20 countries in the world in terms of dams built. We can only build about ten more dams.”

“On the other hand, we must deal with quantity. Previous solutions are not future solutions. When water is recycled, hormones such as oestrogen do not disappear. We must become creative and do something else,” he said.

“Science can make a difference. The UFS is well placed in terms of its groundwater research. Universities must invest in the necessary technology because the testing of toxins is essential. We must work in ways to prevent toxins from re-entering the water cycle,” he said.

A number of international speakers such as Dr Fabrice Renaud, Associate Director at the United Nations University’s Institute for Environment and Human Security (UNU-EHS) in Bonn, Germany, Dr Eugene Poolman, Chief Forecaster: Disaster Risk Reduction, South African Weather Service, and Prof. Rob Bragg from the Department of Microbial, Biochemical and Food Biotechnology at the UFS, attended the conference, as well as attendees from 11 different countries.

At the conference were, from the left: Mr Andries Jordaan, Director: DiMTEC at the UFS; Dr Ing Jörn Birkmann, Head of Section: Vulnerability Assessment at the United Nations University’s Institute for Environment and Human Security (UNU-EHS); Dr Anthony Turton, Director: TouchStone Resources (Pty) Ltd.; and Dr Fabrice Renaud, Associate Director: UNU-EHS.
Photo: Supplied

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