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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Faculty of Theology and Jonathan Edwards Centre at Yale University forge strategic partnership
2009-06-10

 
Prof. Francois Tolmie, Dean of the UFS’s Faculty of Theology.
Photo: Supplied


The Faculty of Theology at the University of the Free State (UFS) will establish a Jonathan Edwards Centre for Southern Africa, affiliated with the Jonathan Edwards Center at Yale University in New Haven in the United States of America.

This strategic partnership exemplifies the vision of the Faculty of Theology to be an internationally renowned theological and training faculty.

The UFS Jonathan Edwards Centre will serve as a research, education and publication hub for the study of Edwards and evangelical history and develop links with the international academic community.

Prof. Francois Tolmie, Dean of the Faculty of Theology at the UFS, said, “I welcome the plans to pay sustained critical attention to Edwards’s thought. Jonathan Edwards was an important American theologian, philosopher and more specifically America's greatest contributor to mission theology in Southern Africa.”

Dr Kenneth Minkema, Executive Director of the Jonathan Edwards Center at Yale University, adds: “The establishment of the Jonathan Edwards Center Southern Africa at the UFS in Bloemfontein is a significant expansion of Edwards scholarship and will serve widely both academia and the church.”

Jonathan Edwards (1703-1758), pastor, revivalist, Christian philosopher, missionary, and president of Princeton University, is widely regarded as North America’s greatest theologian. He is the subject of intense scholarly interest because of his significance as an historical figure and the profound legacy he left on America’s religious, political and intellectual landscapes.

In recent years, a rapidly growing interest in Edwards as theologian has brought the man and his writings onto the world stage, pressing beyond the popular and more parochial image of Edwards primarily as American preacher and American historic figure. Increasingly, his writings are being consulted by religious leaders, pastors, and churches around the world, spurred by a growing recognition of the fervency and universality of the Edwards message and the acumen with which he appraised religious experience.

This interest in Edwards globally has been fuelled in part by the work of the Jonathan Edwards Centre at Yale University, whose sole mission is to support inquiry into the life, writings, and legacy of Jonathan Edwards by providing resources that encourage critical appraisal of the historical importance and contemporary relevance of America’s premier theologian. The primary means to achieve this is with the The Works of Jonathan Edwards Online, a digital learning environment for research, education and publication that presents all of Edwards’s writings, along with helpful editorial materials that allow the reader to examine Edwards's thought in incredibly powerful, useful ways. The Works of Jonathan Edwards Online 2.0 is accessible through the Centre’s website at: www.edwards.yale.edu.

Media Release:
Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
10 June 2009

 

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