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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS academics present papers at major conference

2009-07-23

Pictured from the left are: Prof Neethling, Prof Edna van Harte (Dean of the Faculty of Military Science, Stellenbosch University), Dr Thomas Mandrup (from the Royal Danish Defence College and co-organiser of the conference), and Prof Heidi Hudson.
Photo: Supplied

Prof Theo Neethling from the Department of Political Science was recently invited to address a conference on the theoretical basis for states’ use of military instruments of force and scholarly progress in the understanding of armed conflict in Africa held at Stellenbosch University (SU) on 11 and 12 June 2009. This conference, themed Strategic Theory and Contemporary Africa Conflicts, was presented by the Faculty of Military Science of SU in collaboration with the Faculty of Military and Strategic Studies of the Royal Danish Defence College in Copenhagen. The conference was premised on the point that the way in which states choose to become involved in, orchestrate or oppose armed conflicts in terms of peace intervention action, normally originates from theoretical thinking well-grounded in a national strategy. This was the first conference in South Africa that focused on the nature of such a national strategy, but also on how the incidence of recent armed conflicts in Africa could be explained in terms of this theoretical thinking. In view of this Prof Neethling’s paper was titled, “UN peacekeeping operations in Africa: Reflections on developments, trends and the way forward”. His paper focused on recent and current UN peacekeeping operations with special reference to multinational challenges in the African context.

Prof. Heidi Hudson from the Centre for African Studies also attended the conference in Stellenbosch on Strategic Theory and Contemporary Africa Conflicts. In addition she was invited to present a paper at the Peacekeeping Africa 2009 conference held on 24 and 25 June 2009 at Gallagher Estate, Midrand. The event brings together individuals who are experts in defence, peacekeeping, policing, foreign service and other government bodies to share knowledge and to discuss the latest developments. This year’s conference was attended by more than 100 experts from all over Africa, with strong representation from the UN and the International Red Cross. Prof. Hudson’s paper was entitled “Peacebuilding through a gender lens”. Her presentation examined lessons learnt with regard to implementation of a gender perspective in Côte d’Ivoire and Rwanda. These case studies point towards an empirical link between women’s inclusion in peace processes and the quality of peace finally achieved. Prof. Hudson warned that inattention to the differential needs of both women and men during conflict and in the post-conflict reconstruction phase may perpetuate the violence discourses which sustained the conflict in the first place.

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