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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Students help to get the economy back to the rural areas

2009-08-14

At the launch of Sanlam’s Creativity for Progress Competition for the Ekn 324 group were, from the left: P.J. Bothma, Mr Frank Louw, National Sponsorship Manager of Sanlam, Dr Karen Thomas, lecturer in Economic Policy at the Department of Economics, Kaylee Wells and Eugene Maseme.
Photo: Lacea Loader

Third-year students in the subject Economic Policy Analysis at the UFS are hard at work to think of ideas on how knowledge and expertise can be taken back to the rural areas of South Africa. This is the theme of Sanlam’s national competition for universities called Creativity for Progress with a total prize money of R900 000. This year's topic is "Rural areas are failing to retain and attract skilled people and graduates, resulting in economic stagnation. How would you remedy this?"

The group of 162 students, which is divided into groups of six, must compile a project that is academically grounded, practical and implementable. They must also approach the project from a community service learning perspective and it counts a quarter of their semester mark. To encourage the students, Prof. Tienie Crous, Dean of the Faculty of Economic and Management Sciences, has sponsored some prizes for which the groups must compete. Teams of between four and six members will first compete at intra-varsity level to determine a varsity winner. The national panel members will then adjudicate the varsity winners, and invite the semi finalists to the finals. Teams will be assessed on their business proposals as well as the presentation of these proposals to a panel of judges. Last year the group from the UFS ended second in the final round of the competition.

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