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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS on energy-saving mode

2009-09-15

The University of the Free State (UFS) has undertaken several measures to reduce energy consumption on the Main Campus in Bloemfontein.

“Part of Eskom’s strategy is that all the main universities must reduce their electricity consumption. Because the university is the second biggest user of electricity in Bloemfontein we have to cut our consumption according to the new energy policy,” said Prof. Niel Viljoen, Chief Director of Operations at the UFS.

“Electricity is also expensive and if we look at global warming and everybody’s responsibility, I think we all have a moral obligation to save energy,” said Prof. Viljoen.

“The energy crisis of January 2008 and beyond, with its load-shedding limitations, was a major driver for the government to introduce the Power Conservation Scheme,” said Mr Anton Calitz, the UFS’s electrical engineer.

The measures put in place by the UFS include amongst others:

The introduction of a solar water-heating system in the residences, which is a first of its kind in Bloemfontein.
An investigation is also being launched into alternatives and the effective heating of rooms in the residences.

Feasibility studies are currently being conducted to determine whether energy saving can be achieved with radiation panels.

Energy-saving lights have been installed in the following buildings: the Architecture Building, Genmin Lectorium, Geology lecture halls, Winkie Direko Building, George du Toit Building, Sasol Library, Francois Retief Building, as well as in the residences. This measure has resulted in massive energy saving.

Energy meters for the Library, Computer Laboratory Building, François Retief Building and Steyn Substation are being planned as the first phase.

Real-time metering will result in every UFS computer user being aware of power consumption on the campus.

New lift motors and control systems that reduce energy consumption have been installed at the Agriculture and the George du Toit Buildings.

In the Computer Laboratory Building the temperature adjusting point for the venues is set at 22 °C and, in the case of new projects, green guidelines are applied.

It is expected that the government and local authorities will bring more pressure to bear on the UFS to save energy. Applications for increased capacity will possibly be linked to energy-saving targets.

This trend will continue until 2014 when additional power stations will be put into operation.

“Our aim is to save 10% on energy consumption,” said Prof. Viljoen.

“Heavy financial penalties will be imposed if a 10% saving is not achieved,” added Mr Calitz.

On average, our energy consumption per day this year is 128,964 kWh as compared to last year’s 119,752 kWh.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
14 September 2009

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