Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

The best black and white learners must come and study here

2009-09-17

At the meeting, arranged by the Faculty of Economic and Management Sciences, were from the left: Mr Tshdiso Makoelle, Clocolan High School; Mr Braam van Wyk, St Michael's School in Bloemfontein; Prof. Jonathan Jansen, Rector and Vice-Chancellor of the University of the Free State (UFS); Mr Izak Coetzee, Dr Blok Secondary School in Bloemfontein and Mr Okkie Botha, Witteberg High School in Bethlehem.
Photo: Stephen Collett

“I want to make this university one of the best universities in the country and in the world. For this I will need the support of principals and teachers.” These were the words of Prof. Jonathan Jansen, Rector and Vice-Chancellor of the University of the Free State (UFS) during a recent meeting with school principals held on the Main Campus in Bloemfontein, which was arranged by the Faculty of Economic and Management Sciences.

“I want the best black and white learners to come and study here and therefore I am going to visit schools in the region to find out how we can attract the best learners,” he said.
The most important influence on learners is their teachers and principal. “This why I need the support of teachers and principals to guide their learners to come and study here,” said Prof. Jansen.

Prof. Jansen said that it was of no use to work with Grade 11 and 12 learners only as it was mostly too late to change their minds. He wants to work with Grade 10 learners and make them excited about university life so that they will know what the UFS can offer them. He will also visit poor and rural schools and tell them about the UFS.

“When a Kovsie graduate walks down the street something must distinguish him/her from other graduates. Our graduates must be able to work anywhere in the world,” he said.

“Students must have the ability to live with other people and to be comfortable around people who look and speak differently than them. I want our students to be multi-lingual and to be comfortable around other students and people in terms of religion, race, language, etc. Students who do not have this added value will not be successful in the market,” he said.

Media Release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
16 September 2009

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept