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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS hockey teams crowned as Free State hockey champions

2009-09-21

The University of the Free State’s (UFS) men’s and women’s hockey teams were recently crowned as the Free State hockey champions during the championship that took place on the university's astro fields in Bloemfontein.

Kovsie women defeated Raiders (the defending champions) 6-0 and the Kovsie men’s hockey team successfully defended their title against Tweespruit. During a penalty shootout UFS Reds beat the team of the Central University of Technology (CUT 1) 8-7, thereby ending in the third position.

Very early on the Kovsie women’s hockey team showed that they wanted to break the five-year drought without a trophy and within the first ten minutes they took the lead with 2-0 against Raiders. Liza Dreyer scored her first two goals out of four and from that moment on the Raiders were with their backs against the wall. With the score of 4-0 at halftime it was clear that Kovsies would have a second trophy in their cupboard after their recent success during the USSA championships. After halftime, Odie Swart scored another goal from a penalty corner and Liza scored her fourth goal, to bring the end score to 6-0. Malisa Kala was the other Kovsie who scored a goal.

Odie Swart, captain of the Kovsies played her last match for the Kovsies with Cat van Zuydam. She excelled in the attack as well as in the defence.

The Kovsies men’s hockey team has now done it three out of three times! Within the first twenty minutes the Kovsies men’s hockey team defeated Tweespruit with brilliant hockey by scoring three goals. Luke Sanan (2) and Kurt Henzberg (1) scored the goals. All three the goals were well-executed field goals. The current Kovsie team is surely the best-rounded hockey team that the Free State has had over the last ten years. In the past three years the students played in more than 45 club matches and they did not lose one match!

With the joy also comes sadness. For Braam van Wyk it was his last match as coach of a Kovsie team. For the past 17 years Braam has been involved with Kovsie hockey, in which he led the girls to twelve victories in the Free State league. The last three years he managed the men’s team, who won the league for the past three consecutive years, indeed an achievement. With Braam, three other senior players of the past three years made their last appearance for Kovsies. They are Morne Odendaal, Renaldo Ogle and Braam van Wyk (jr.).

Literally during the last moments of their game against CUT 1, the UFS Reds, who were 1-4 behind, scored a goal, which brought the final score to 4-4. The Kovsie students won the penalty shootout with 4-3, thereby winning 8-7 and thus ending third in this year’s men’s Free State league.

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