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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

CED holds Family Math and Science summit

2009-10-06

At the summit were, from the left: Ms Lorraine Botha(CED); Susan Koen (Coordinator: Frances Baard, Northern Cape); Prof Daniella Coetzee-Manning (Director: CED); Elizna Prinsloo (Project Coordinator: CED); Magriet Fourie (Coordinator: Qwa-Qwa); Anne-Marie Lochner (Coordinator: Namakwa).
Photo: Mangaliso Radebe

The Centre for Education Development (CED) at the University of the Free State launched its Family Math & Family Science roll-out initiative in the Free State and Northern Cape Province at the beginning of 2009. As part of the quality assurance process, a Family Math & Family Science Summit was recently held at the CED to reflect upon the roll-out strategy during 2009. Delegates as far as Qwaqwa in the Free State and De Aar and Springbok in the Northern Cape province, sponsors and other role-players attended the summit to share information regarding the impact and best practices of the roll-out strategy.

The mission of the project is to demystify Math and Science for learners in the early school years by raising their levels of understanding and changing their attitudes towards Sciences and Mathematics. This is done by exposing learners to Family Math & Family Science activities on a regular basis in the classroom and integrating the activities into the curriculum.

A total number of 5112 learners from predominately rural communities in the Free State and Northern Cape provinces were actively involved in doing Math and Science activities during the first 3 terms of 2009. To achieve this, the CED trained 9 Subject Advisors to act as coordinators in their respective regions with the responsibility of training and supporting local teachers in the implementation of the progamme. One of the key elements of the success of the project is the fact that the CED also manufactures and issues the 134 participating teachers with sufficient training material like manipulatives and other activity material to be utilized in the classroom. Without the support of the sponsors, ABSA and SANRAL, the latter would not have been possible.

It is envisaged to include as many schools as possible in the Free State and Northern Cape province in the programme, depending on sponsorships received.

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