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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsies shine at USSA Cross Country Championships

2009-10-15

Thandi Malindi (far left) from the UFS and two Matie athletes, Elene Lourens and Mia Pienaar.
Photo: Supplied

Kovsie cross-country athletes Boy Soke and Thandi Malindi were included in the USSA squad for 2010 at the World Student Cross-Country Championships in Canada. The final team will be announced after the SA Cross-Country Championships. They recently participated in the USSA Cross-Country Championships that were held at the University of Johannesburg. According to Mr DB Prinsloo from KovsieSport at the University of the Free State, the UFS team did extremely well at the recent USSA Cross-Country Championships.

Kovsies won the women long-race team competition (8 km), while the men came second in the men’s long-race team (10 km) competition. In the short-race team competitions (4 km for men and women) the UFS men finished fourth and women ended in fifth place respectively.

Thandi Malindi, the UFS Women Cross-Country captain, was the first Kovsie over the line (third place), followed by Nelmarie Loubser (4th) and Maryna Swanepoel (6th), who also won the team competition in the 8 km (long race) with 13 penalty points against the 14 penalty points of the Maties who finished second.

Mr DB Prinsloo from KovsieSport at the UFS praised the Kovsie athletes for the manner in which they ran the race. “Thandi gave her all; so much so that she had to be admitted to hospital due to dehydration. Nelmaré ran the hills with a smile on her face and Maryna, who suffered from low blood sugar, persevered until the end so that a Matie athlete could not pass her. You all showed to us what ‘vasbyt’ really means,” Mr Prinsloo said.

Kovsies performed above expectation in the short race (4 km) for women. “Our women finished fifth in the team competition. If one takes into consideration that the Kovsies were represented by 400/800 athletes, i.e. Elri Richter (400/800), who came seventh, Anneri Ebersohn (400/400 hurdles), who ended in sixteenth place and Yvonne Eyssen (heptathlon) who ended in twentieth place, it makes this performance even better,” Mr Prinsloo commented.

In the men’s short race (4 km) where the Kovsies were represented by young first-year 800 m athletes, the UFS did excellently by finishing in fourth place. Hanne Naudé (18th), Lebohang Mpure (19th), Abri Horak (26th) and Gerrit Viljoen (34st) ran their hearts out!

The long race (10 km) for men, which was run on an extremely difficult course, was another highlight – also for the Kovsies. The Kovsies finished second in the team competition. Boy Soke (4th), Windy Jonas (8th), Schadrach Mochelenyane (10th) en Michael Tlhoro (21st) represented the Kovsies with honours. Unfortunately Johan Cronjé and Dumisane Hlaselo had to withdraw from the race due to injuries.

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