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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Clarification of charges against the Reitz students

2009-10-24

Statement by Prof. Jonathan Jansen, Rector and Vice-Chancellor of the University of the Free State (UFS)

The University of the Free State (UFS) has not “withdrawn charges” against the four Reitz students. This needs to be clarified.

There are three processes underway, and they must not be confused:

1. The criminal charges against the students were laid by the Directorate of Special Prosecutions in the province, and the university has no say over those processes in the criminal courts. That process remains in place.
The human rights charges are led by the Human Rights Commission, in the province, and the university has no say over those processes in the equality court. That process remains in place.
The university simply withdrew its own complaint against the students, insofar as university processes are concerned, and on that basis decided to invite the students back to continue their studies and to re-open Reitz as a model of social justice and racial reconciliation as an exemplary university residence. These decisions alone fall within the realm of the university’s authority.

The decision with respect to the withdrawal of the university’s complaint against the students was based on two considerations:

a. the institution’s own accountability for what happened, and creating (or not interrupting) the conditions under which racism and racist attacks were even possible on the campus of an institution of higher learning. It is in this context that the institution has decided to offer reparations for harm to the dignity and esteem of the five workers.

b. the institution’s desire to create the conditions for racial reconciliation on a deeply divided campus, and in doing so to accelerate the chances of transformation at the UFS.

There were broad consultations with the Human Rights Commission, Cosatu provincial, Sasco, Nehawu as representatives of the workers; there were also discussions with the leadership of the Student Representative Council (SRC) about the need to resolve the Reitz issue outside of the courts; and the matter of Reitz and its resolution through negotiation was also raised with the Minister of Higher Education and Training. There were also meetings with the legal representatives of both the students and the provincial prosecuting authority.

There was a meeting with the workers to ensure them of the university’s full support for them as workers, but the case itself was only discussed with their representatives, Nehawu.

Sasco National has communicated a message of support to the university to return the two students and to re-open the Reitz residence.

Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
19 October 2009

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