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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS appoints a Dean of Education

2009-11-06

Prof. Dennis Francis, Dean of the Faculty of Education at the University of the Free State (UFS).

Prof. Dennis Francis from the University of KwaZulu-Natal has been appointed as Dean of the Faculty of Education at the University of the Free State (UFS) as from 4 January 2010. He is the first dean of this faculty since it was established at the UFS earlier this year.

Prof. Francis has worked at the University of KwaZulu-Natal since 2002. Prior to his appointment at the UFS he was a Professor in the Faculty of Education and Head of the School of Social Science Education at that institution.

“I am overwhelmed and excited at the same time. Mostly, I feel privileged and honoured to be joining the Faculty of Education,” he said of his appointment.
“The Faculty of Education is newly constituted and there are endless possibilities and potential. So I am really excited to be here.”

“What attracted me to the UFS is the leadership and vision of Prof. Jonathan Jansen, the emergent energy that is here, and the possibilities for transformation and change that exist. But also the warmth and graciousness of the people that I have interacted with,” he said.

Prof. Francis has taught and supervised Master’s and Doctoral students in the area of social justice education, identity studies and sexuality education. He has published numerous articles in refereed national and international journals, chapters in edited collections, and four edited journal special issues. He is also the author of Between Race; Beyond Race. Prof. Francis is the current guest editor of the South African Journal of Higher Education Special Issue on Transformation and Social Cohesion in Higher Education.

He has delivered conference presentations in his fields of research at international conferences in India, USA, Brazil, Thailand, Greece, Malaysia, Mauritius, UK and South Africa, as well as a further fifteen papers at national conferences. At three of these conferences he was an invited speaker. In 2008 he was granted researcher status by the National Research Fund.

Prof. Francis is currently on the editorial boards of two journals and an advisor on two international education conference committees. He also serves as the Chairperson of the Kenton Education Association.

Media release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
5 November 2009

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