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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS student registration shows good progress

2005-01-31

The registration of students on the main campus of the University of the Free State (UFS) is on track and is progressing well. More than 2000 first-time entering first-year students have already registered.

“We are happy with the registration progress and have experienced no major problems. Other than last year, the registration of all students is taking place in the Callie Human Centre. A one stop service is available to students on the premises – among others advice on bursaries, loans, staff and council bursaries, enquiries for international students, information on class and room tables, student cards, vehicle permits etc, “said Mr Vernon Collett, Registrar: Academic Student Services at the UFS.

According to Mr Collett students are registered on the UFS’s new PeopleSoft

software programme, which was installed last year.

“In the past a student’s data had to be captured and he/she had to wait for a proof of registration. This prolonged the registration process. This year the Callie Human Centre was equipped with a complete data capturing centre comprising of 85 computers. Students no longer have to stand and wait for a proof of registration. An SMS is sent to the student per cell phone within 48 hours to confirm whether the registration was successful or not. Students can also track their registration information on the UFS web site,” said Mr Collett.

Senior undergraduate students may register until 29 January 2005 and postgraduate students, first-time entering first-year students and other students who applied for admission after 30 November 2004 until 15 January 2005 , may register from 31 January- 4 February 2005 according to a programme. Senior students who have not register yet, will also be allowed to register from 31 January 2005-4 February 2005 according to the scheduled programme.

According to Mr Collett postgraduate students who applied for admission from 15 January- 11 February 2005 , may register according to a programme from 7-11 February 2005. Students who want to change their field of study or want to amend their modules, may do so during this period.

“Pipeline students from Vista must register on the UFS’s Vista campus on the dates already mentioned and first-year students from Vista must register on the UFS’s main campus. These students, including students on the UFS’s Qwaqwa campus, may register until 11 February 2005 ,” said Mr Collett.

Lectures at the UFS’s main campus as well as the Vista- and Qwaqwa-campusses will commence on 31 January 2005 .

A complete registration programme is available on the UFS’s web site at www.uovs.ac.za.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
28 January 2005

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