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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Centenary celebrations of Faculty of Law reach a highlight
2009-11-19

At the occasion were, from the left: the Honourable Judge Ian van der Merwe; the Honorable Judge Faan Hancke; former Judge of Appeal Joos Hefer; and Prof. Johan Henning, Dean of the Faculty of Law at the UFS.
Photo: Stephen Collett


The Faculty of Law at the University of the Free State (UFS) reached the highlight of its celebrations of a century of excellence in legal education, training and research under the theme “Iurisprudentia 100” at a gala dinner held on the Main Campus in Bloemfontein last week.

At this spectacular occasion Prof. Johan Henning, Dean of the Faculty handed a Cum Laude award to Judge Faan Hancke, Chairperson of the UFS Council and Extraordinary Professor in the Department of Law of Procedure and Law of Evidence. Judge Hancke is the fourth recipient of this award. Judge Hancke received the award for his excellent contributions towards the building of the Faculty of Law and the UFS.

According to Prof. Henning the faculty has a distinguished history of excellence in theoretical as well as practical education and training, which can be traced as far back as to the establishment of the Grey University College in 1904. During this modest beginning the seed was planted for the establishment of the Faculty of Law, which gained momentum when Bloemfontein became the judicial capital of South Africa in 1910.

Other highlights in legal education at the UFS include, amongst others, 1909 when Adv. Percy Fisher, a BA LLB graduate from the University of Cambridge became the first law lecturer to receive a permanent appointment. In 1918 the first LLB degrees were awarded to SP le Roux, later Minister of Agriculture, CR Swart, later Minister of Justice, Governor-General, State President and the first Chancellor of the UFS, and Walther Leinberger, an attorney in town.

In 1945 Law became an independent faculty and in 1948 the first full-time professor, Dr JP Verloren van Themaat was appointed. After Prof. Van Themaat, six deans followed before the appointment of Prof. Henning.

Over the last ten years the faculty has managed to build many international contacts with international leaders in the legal arena, including the Universities of London, Cambridge, Sussex, Tilburg, Kentucky, Heidelberg, Freiburg, Utrecht and Deacon.

The faculty prides itself on the fact that he has prepared many students as well as lecturers who later became presidents, ministers, administrators, judges of appeal, judges and rectors. The faculty has 95 staff members and 2 400 students, of which 1 800 are postgraduate students.

National as well as international leaders in the legal field congratulated the faculty on its 100-year celebrations. Messages of congratulations were also received from, amongst others, universities, legal practices and the government.

Media release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 November 2009
 

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