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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS will increase its volume of quality research
2009-11-25

 
From the left are, seated: Prof. Alice Pell, Vice-Provost: International Relations at Cornell University in the USA and Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS; standing: Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS, and Prof. David Wolfe from Cornell University during the signing of a memorandum of agreement between the two institutions.
Photo: Stephen Collett

The University of the Free State (UFS) is taking its research serious and is therefore going to increase its volume of quality research. This includes the production of quality scholarly books in the humanities and social sciences.

This was said by Prof. Jonathan Jansen, Rector and Vice-Chancellor, at the launch of the Strategic Academic Cluster initiative of the University on the Main Campus in Bloemfontein last night.

“We are going to produce the kind of research that is associated with scholarships. New models of training, new standards of performance and the introduction of an accelerated Vice-Chancellor’s Prestige Scholars’ Programme are among the initiatives that will be introduced. These are all aimed at boosting our university’s research performance,” said Prof. Jansen.

Another strategy to boost research performance at the UFS is the search for 25 leading professors to be appointed across the disciplines, but especially in the social sciences, education and the humanities. These positions have already been advertised and will be phased in with the goal of achieving equity and excellence in the academic and research profile of the UFS. “We’ve had an overwhelming response to the advertisements from local academics as well as those abroad,” said Prof. Jansen.

Each of the six Cluster Directors gave a short presentation of its aim and focus areas during last night’s dinner. These Clusters will in future direct the University’s research endeavours. It represents a move from a fragmented to a more focused approach to research development at the UFS.

The UFS also signed a memorandum of agreement with Cornell University (USA) last night. The guest speaker, Prof. Alice Pell, Vice-Provost: International Relations at Cornell University and member of the UFS’s International Advisory Board, said that, just as the cluster research teams need representatives from different disciplines, universities need diverse partners to recognise their potential fully. Collaborating with partners with ‘fresh eyes’ that have different cultural perspectives, access to different technologies and partners with different priorities can have important implications in the research and education provided by the UFS and Cornell,” she said.

“The interdisciplinary approach adopted by the UFS in developing the Strategic Academic Clusters seems likely to provide students with the intellectual frameworks and research tools that they need to address the problems in society,” she said.

“The most important issues facing the USA and South Africa are similar, namely how to effect the social transformation that will provide equal opportunities to all of our citizens. South Africa, Brazil, India and the USA share strong commitments to democracy, to overcoming our dark histories of religious and racial discrimination and to sustainable economic development without adverse impacts on our planet. We at Cornell are excited about the opportunity to work with the UFS on all of the clusters, but we are particularly looking forward to learning more about social transformation,” said Prof. Pell.

Media release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
24 November 2009

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