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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Research at the UFS on the acceptability and modern use of earth building in newly settled urban areas can help the poorest of the poor to acquire hou
2003-08-26

The University of the Free State and the Technische Universiteit van Eindhoven in the Netherlands received a research bursary of R316 000 from SANPAD (South African Netherlands Research Programme on Alternatives in Development).

The aim of the research is to determine the public acceptability of sustainable, high quality, earth constructed public and private buildings as an alternative to the conventional way of building with bricks and steel.

“European countries like the Netherlands are far advanced with studies in earth construction and this is why the partnership was formed with the Technische Universiteit van Eindhoven,” says Prof Das Steÿn, Head of Urban and Regional Planning at the UFS and project leader.

Although research regarding mapping, typology and availability of natural and local resources has been done on a national level, little research has been done on the acceptability and the modern use of earth building in newly settled urban areas.

“South Africa has a large housing shortage and traditional methods such as earth building techniques are not used in urban informal housing. Preference is given to corrugated iron sheets and plastic,” says Prof Steÿn.

The use of upgraded earth construction might be more sustainable as far as the environment and the economy is concerned. “If we can make a breakthrough in the development and propagating of these methods it will help the poorest of the poor to acquire housing of a better quality.”

The research team from the UFS consists of Prof Steÿn, Ms Petria Jooste-Smit, Head of the Unit for Earth Construction in the Department of Architecture and Mr Gerhard Bosman of the Department of Architecture.
 

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