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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Academic produces another book

2009-12-01

Academic, author and motivational speaker, Dr Michael van Wyk (pictured), has written another book titled Cooperative learning as a teaching strategy for the classroom: A practical guide for economics teachers.

His latest offering provides a sound theoretical framework and practical ways on how to implement the different cooperative learning techniques. It unpacks the practical aspects of the outcomes-based approach, the National Curriculum Statement for the Further Education and Training phase and cooperative learning techniques for the economics classroom.

This easy-to-read book offers a thorough introductory text for economics teachers and economics students, as well as lecturers and researchers.

“This theoretical and practical guide will support Economics teachers to present their subject in practical ways that are meaningful and learner centred,” he said.

“If this can be achieved, learners will engage effectively in the subject and an interest in the learning content may be evoked.”

The book covers the following aspects:

It introduces the foundations of the outcomes-based education approach (OBE) and the new curriculum model for South African schools.
It examines the theoretical underpinnings and practical application of cooperative learning as a teaching strategy.
It provides practical guidelines for application of cooperative learning techniques.

“This book gives an outline, in a constructive way, on how to apply the cooperative learning techniques such as Teams Games Tournaments (TGT), Student Teams Achievement Divisions (STAD), role-play, simulations, Economics quizzes, small group teaching and research projects in the classroom,” he said.

“These techniques have the potential to make a positive contribution to the enhancement of academic performances, development of social skills and an improvement of the learning skills of the learners.”

The book is designed as a theoretical and practical guide for Economics Education students, Economics teachers, Learning Area Economics and Management Science facilitators, Curriculum developers, Economics subject advisors, researchers and trainers; for the successful implementation of cooperative learning as a teaching strategy.

Dr Van Wyk is a staff member of the Department of Curriculum Studies in the Faculty of Education at the University of the Free State (UFS). He also serves on the board of the South African Foundation on Economics and Financial Education (SAFEFE).

Photo: Mangaliso Radebe

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