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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS welcomes the class of 2010

2010-01-13

Pictured with Prof Jansen are, from the left: Christo Smal (B.Sc. Quantity Surveying student from Bloemfontein), Nicole Tarentaal (LL.B. student from Bloemfontein), Charmoné Swartz (LL.B. student from Kimberley) and Lizé de Witt (B.Sc. Quantity Surveying student from Bloemfontein).
Photo: Stephen Collett

The University of the Free State (UFS) welcomed its first-time entering first-year students on the Main Campus in Bloemfontein this past weekend.

Addressing the new students and their parents at the ceremony, the Rector and Vice-Chancellor Prof. Jonathan Jansen assured the new students and their parents that “they are at the right place”.

“We will not cut corners with your child’s education as we are serious about the quality of the education we provide,” he said to the parents. “We shall make sure that our students are distinguished among graduates from other universities – that they are leaders. Quality is not negotiable.”

Prof. Jansen also said the standards of admission at the UFS would be raised. “We need students of a higher academic standard,” he said.

“Our students will obtain a degree they will be proud of. We are going to put everything into their education and experience here at the UFS so that they can be the best in their field of study.”

He told the new students and their parents that they were safe at the UFS as no first-year student would be initiated anymore. He said that there were other ways to create self-respect and confidence in a young person without having to use initiation.

“It is not enough to have a degree,” he said. “We want to link your degree to thorough preparation for the workplace. Your degree must be accepted globally.”

Prof. Jansen further emphasised the importance of students to understand one another and to get along with one another – especially with those who speak a language different from their own and with a different skin colour than theirs.

“Our students must have respect for one another. This is a value that should be added to your qualification in order for you to be relevant in the workplace anywhere in the world.”

He said the university was busy with a programme to install computer points in all the residences. He also extolled the virtues of the UFS, citing excellence in sport, music, debating and other activities.

Prof. Jansen also reiterated the fact that the first group of 100 first-year students who would be sent overseas to study during the second semester would come from this class of 2010.

“The class of 2010 will change Kovsies. They will be the best students that have ever graduated,” he said.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za
12 January 2010

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